81449-01-6

Basic information

• Product Name: Methanone, [4-(hydroxyMethyl)phenyl]phenyl-
• Synonyms: Methanone, [4-(hydroxyMethyl)phenyl]phenyl-;(4-(HydroxyMethyl)phenyl)(phenyl)Methanone
• CAS NO: 81449-01-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24388
• Mol File: 81449-01-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methanone, [4-(hydroxyMethyl)phenyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4-(hydroxyMethyl)phenyl]phenyl-(81449-01-6)
• EPA Substance Registry System: Methanone, [4-(hydroxyMethyl)phenyl]phenyl-(81449-01-6)

Safety Data

• Hazardous Substances Data: 81449-01-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis and Pharmaceutical Research:
Methanone, [4-(hydroxymethyl)phenyl]phenylis used as a building block for the synthesis of various pharmaceuticals and fine chemicals, contributing to the development of new drugs and chemical compounds.
Used in Cosmetics and Personal Care Industry:
Methanone, [4-(hydroxymethyl)phenyl]phenylis used as a fragrance ingredient in the cosmetics and personal care industry, providing pleasant scents to various products.
Used in Dyes and Pigments Production:
Methanone, [4-(hydroxymethyl)phenyl]phenylis used in the production of dyes and pigments, contributing to the coloration of various materials and products.
Used in Agricultural Chemicals Production:
Methanone, [4-(hydroxymethyl)phenyl]phenylis used as an intermediate in the production of certain agricultural chemicals, playing a role in the development of effective and safe agrochemicals.
Used in Food Industry:
Methanone, [4-(hydroxymethyl)phenyl]phenylis used as a flavoring agent in the food industry, enhancing the taste and aroma of various food products.

Upstream product

• 67-56-1 methanol 
• 119-61-9 benzophenone 
• 15165-27-2 ethyl 4-benzoylbenzoate 
• 52010-97-6 4-(hydroxylmethyl)benzaldehyde 
• 623-27-8 terephthalaldehyde, 
• 88682-29-5 4-(1-hydroxy-1-phenylmethyl)benzyl alcohol 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 50-00-0 formaldehyd 
• 611-95-0 4-carboxybenzophenone 
• 1616844-72-4 methyl 4-(2-phenyl-1,3-dioxolan-2-yl)benzoate 
• 6158-54-9 methyl 4-Benzoylbenzoate 
• 134-85-0 4-chlorobenzophenone 
• 134-84-9 4-Methylbenzophenone 

Downstream Products

• 30568-20-8 p-Benzoyl-zimtsaeure-methylester 
• 30568-19-5 α-Chlor-p-benzoyl-hydrozimtsaeure-methylester 
• 30568-21-9 2.3.3-trichlor-1--propen-(2) 
• 185686-39-9 (E,E)-[4-(2',6'-dimethyl-8'-tetrahydropyranyl-2''-oxy-octa-2',6'-dienyloxy)-methylphenyl]-phenyl-methanone 
• 20912-50-9 4-benzoylbenzaldehyde 
• 1146295-87-5 4-[(tributylstannyl)oxymethyl]-benzophenone 
• 1008513-70-9 4-Hydroxymethyl benzophenone hydrazone 
• 201275-75-4 4-(allyloxymethyl)benzophenone 
• 74839-99-9 p-benzoylcinnamic acid 
• 205443-12-5 (3-Ethylsulfanyl-2,5-dioxo-pyrrolidin-1-yl)-acetic acid 4-(1-hydroxy-1-phenyl-2-propionylamino-ethyl)-benzyl ester 
• 205443-10-3 (3-Ethylsulfanyl-2,5-dioxo-pyrrolidin-1-yl)-acetic acid 4-benzoyl-benzyl ester 
• 205443-08-9 (2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-acetic acid 4-benzoyl-benzyl ester 

Relevant articles and documents

Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels

To locate the binding sites of general anesthetics on ligand-gated ion channels, two derivatives of the intravenous general anesthetic etomidate (2-ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate), in which the 2-ethyl group has been replaced by photoact

Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity

A series of 19 novel pyrido-imidazodiazepinones, with modulations of positions 2, 3 and 4 of the diazepine ring were synthesised and screened for their in vitro cytotoxic activities against two melanoma cell lines (A375 and MDA-MB-435) and for their poten

Chemoselective reduction of aldehydes: Via a combination of NaBH4 and acetylacetone

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient chemoselective reduction of aldehydes in the presence of ketones. This method offers a useful synthetic protocol for distinguishing carbonyl reaction sites, and its synthetic utility is reflected by its moisture tolerance and high efficiency in a variety of complex settings.

An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: A new facet to classical DMSO oxidation

A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols. The developed protocol utilizes the electrophilic center of DMSO for oxidation, which was unexplored before. Mechanistic investigation has confirmed that the source of oxygen is DMSO.

Transition-metal-free, ambient-pressure carbonylative cross-coupling reactions of aryl halides with potassium aryltrifluoroborates

We disclose an unprecedented transition-metal-free carbonylative cross coupling of aryl halides with potassium aryl trifluoroborates even at atmospheric pressure of carbon monoxide. This protocol is efficient, operationally simple, and shows wide scope with regard to both aryl halides and potassium aryl trifluoroborates containing a series of active functional groups.

Selective aldehyde reduction in ketoaldehydes with NaBH4-Na 2CO3-H2O at room temperatures

A variety of aliphatic and aromatic ketoaldehydes were reduced to the corresponding ketoalcohols with a mixture of sodium borohydride (1.2 equivalents) and sodium carbonate (sixfold molar excess) in water. Reactions were performed at room temperatures(typically) 2 h, and yields of isolated products generally ranged from 70% to 85%. A bis-carbonate-borane complex, [(BH3)2CO2]2- 2Na+, possibly formed from the reagent mixture, is likely the active reductant. The moderated reactivity of this acylborane species would explain the chemoselectivity observed in the reactions. The readily available reagents and the mild aqueous conditions make for ease of operation and environmental compatibility, and make a useful addition to available methodology. Copyright

Palladium-catalyzed hydroxymethylation of aryl-and heteroarylboronic acids using aqueous formaldehyde

Cyclometallated NHC palladium complexes prepared from palladium(II) acetate [Pd(OAc)2] and unsymmetrical 1,3-diarylimidazolinium salts catalyzed the hydroxymethylation of (hetero)arylboronic acids using an excess amount of formalin to afford (hetero)arylm

Palladium-catalyzed arylation of aldehydes with bromo-substituted 1,3-diaryl-imidazoline carbene ligand

The combination of 0 valent palladium precursor and bromo-substituted 1,3-diaryl-imidazoline carbene ligand precursor such as 1-(2-bromophenyl)-3-(2,6-diisopropylphenyl)-imidazolinium chloride 1a exhibited high catalytic activity for the 1,2-addition of arylboronic acids to aldehydes including aqueous formaldehyde.

CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

Palladium-catalyzed direct hydroxymethylation of aryl halides and triflates with potassium acetoxymethyltrifluoroborate

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.