185689-38-7

Upstream product

• 20877-81-0 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 
• 185689-39-8 5-methyl-6-nitro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 185689-42-3 6-amino-5-methyl-1H-benzo[d][1,3]oxazin-2,4-dione 
• 185689-41-2 1,1-dimethylethyl(1,4-dihydro-5-methyl-2,4-dioxo-2H-3,1-benzoxazin-6-yl)carbamate 

Downstream Products

• 185687-25-6 6-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methyl-2-[[(1R)-phenylethyl]amino]-4H-3,1-benzoxazin-4-one 
• 767609-43-8 6-amino-5-methyl-2-[[(1R)-phenylethyl]amino]-4H-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

2-AMINO-BENZOXAZINONES FOR THE TREATMENT OF VIRAL INFECTIONS

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II STR1 wherein R 28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R 29 is selected from hydrido, alkyl, halo, STR2 wherein R 30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R 31 is alkyl; wherein R 32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.

Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture.

A series of 2-amino substituted benzoxazinones were prepared that potently inhibit human cytomegalovirus protease in vitro. Selected compounds demonstrate antiviral activity in cell culture, selectivity relative to chymotrypsin and elastase and stability with respect to hydrolysis in human plasma.