20877-81-0

Basic information

• Product Name: 6-Methylisatoic anhydride
• Synonyms: 5-methyl-2H-3,1-benzoxazin-2,4(1H)-dione;5-methyl-1H-3,1-benzoxazine-2,4-dione
• CAS NO: 20877-81-0
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.15678
• Mol File: 20877-81-0.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Methylisatoic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methylisatoic anhydride(20877-81-0)
• EPA Substance Registry System: 6-Methylisatoic anhydride(20877-81-0)

Safety Data

• Hazardous Substances Data: 20877-81-0(Hazardous Substances Data)

Upstream product

• 1128-44-5 4-methyl-1H-indole-2,3-dione 
• 269391-47-1 2-{((1,1-Dimethylethoxy)carbonyl]amino)-6-methylbenzoic acid 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 75-44-5 phosgene 

Downstream Products

• 686265-99-6 1-benzyl-(4-methyl)benzo[2,3-d][1,3]oxazine-2,4-dione 
• 1337543-02-8 ethyl 4-(4-methoxybenzylamino)-2,5-dimethylquinoline-3-carboxylate 
• 258508-84-8 methyl 2-amino-5-bromo-6-methyl-3-nitrobenzoate 
• 258508-85-9 methyl 2,3-diamino-6-methyl benzoate 
• 943138-48-5 C₁₁H₁₃NO₂ 
• 573692-58-7 methyl 6-amino-3-bromo-2-methylbenzoate 
• 943138-57-6 C₁₃H₁₉NO₂ 

Relevant articles and documents

Synthesis of novel quinoxaline-5-carboxylic acid derivatives

This paper describes the synthesis of several new 2,3-dimethoxy-6- methyl-7-nitro-quinoxaline-5-carboxylic acid derivatives (13a-m) via a multistep synthetic route from 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione (1).

Target protein degradation inducing compound, preparation method thereof and pharmaceutical composition for preventing or treating targeted protein related diseases containing the same as an active ingredient

The present invention relates to a degraducer for inducing the decomposition of target protein, a producing method thereof, and a pharmaceutical composition for preventing or treating target protein-related diseases by containing the degraducer as an active ingredient. A novel compound represented by chemical formula 1, ULB-L-PTM, by the present invention, as a degraducer compound inducing the decomposition of target protein using cereblon E3 ubiquitin ligase, is able to significantly achieve a target protein degradation-inducing activity with an excellent binding activity of a cereblon E3 ubiquitin ligase binder thereby, being able to achieve an excellent protein degradation activity by targeting protein or polypeptide related to various diseases. The bromodomain-containing pharmaceutical composition for preventing or treating protein-related diseases or conditions contains the novel compound represented by chemical formula 1 as an active ingredient and has a useful effect of providing a health functional food composition for prevention or improvement.(AA) Example 22 (nM, 24h)COPYRIGHT KIPO 2020

Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using p Ka-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam 3, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.