185739-16-6Relevant articles and documents
Visible-Light-Mediated Z -Stereoselective Monoalkylation of β,β-Dichlorostyrenes by Photoredox/Nickel Dual Catalysis
Abdellaoui, Mehdi,Millanvois, Alexandre,Levernier, Etienne,Ollivier, Cyril,Fensterbank, Louis
supporting information, p. 1513 - 1518 (2021/02/26)
Metal-catalyzed alkylation of 1,1-dihalovinyl moiety commonly suffers from both a lack of stereoselectivity and the overreaction leading to the dialkylation product. The methodology described herein features a new pathway to alkylate stereoselectively β,β-dichlorostyryl substrates to provide the Z -trisubstituted olefin only with fair to good yields. This cross-coupling reaction bears on the smooth and photoinduced formation of a C-centered radical that engages in a nickel-catalyzed organometallic cycle to form the key C sp2-C sp3bond.
Highly E-Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates
Li, Yuxiu,Li, Xiangqian,Li, Xiaowei,Shi, Dayong
, p. 6983 - 6993 (2021/05/06)
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal-and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
