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17556-44-4

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17556-44-4 Usage

General Description

2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol is a chemical compound with the molecular formula C12H11F3O. It is a fluorinated alcohol with a naphthalene ring attached to the carbon atom. 2,2,2-trifluoro-1-(naphthalen-1-yl)ethanol is used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It can also be employed as a solvent in chemical reactions and as a reagent in the synthesis of other fluorinated compounds. Additionally, its fluoro-substituted structure makes it an interesting candidate for further research in the development of new materials and pharmaceuticals with specific fluorine-containing functionalities.

Check Digit Verification of cas no

The CAS Registry Mumber 17556-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,5 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17556-44:
(7*1)+(6*7)+(5*5)+(4*5)+(3*6)+(2*4)+(1*4)=124
124 % 10 = 4
So 17556-44-4 is a valid CAS Registry Number.

17556-44-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2,2-trifluoro-1-naphthalen-1-ylethanol

1.2 Other means of identification

Product number -
Other names 1-naphthyl-2,2,2-trifluoroethan-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17556-44-4 SDS

17556-44-4Relevant articles and documents

Pirkle,Hoekstra

, p. 3904 (1974)

One-Pot Successive Turbo Grignard Reactions for the Facile Synthesis of α-Aryl-α-Trifluoromethyl Alcohols

Kani, Ryunosuke,Inuzuka, Toshiyasu,Kubota, Yasuhiro,Funabiki, Kazumasa

supporting information, p. 4487 - 4493 (2020/06/01)

A novel straightforward one-pot methodology for two successive turbo Grignard reagent (iPrMgCl·LiCl) reactions, was developed for a facile synthesis of α-aryl-α-trifluoromethyl alcohols, motifs of value in pharmaceutical chemistry. The method displayed broad functional group tolerance, including reducible groups. Dual roles of iPrMgCl·LiCl were exploited in the tandem reaction with commercially available iodoarenes or iodoheteroarenes and 2,2,2-trifluoroethyl trifluoroacetate. The process encompasses three successive reactions in a one-pot process: the iPrMgCl·LiCl-mediated iodine/magnesium-exchange reaction of iodoarenes or iodoheteroarenes; nucleophilic addition of various generated aryl or heteroarylmagnesium reagents to 2,2,2-trifluoroethyl trifluoroacetate; and the reduction of in-situ generated aryl trifluoromethyl ketones with iPrMgCl·LiCl, to produce the corresponding α-aryl or α-heteroaryl-α-trifluoromethyl alcohols bearing various substituents, including reducible functional groups in good to excellent yields.

Palladium-Catalyzed Direct Approach to α-Trifluoromethyl Alcohols by Selective Hydroxylfluorination of gem-Difluoroalkenes

Zhang, Bin,Zhang, Xiaofei,Hao, Jian,Yang, Chunhao

, p. 5007 - 5015 (2018/10/05)

A novel palladium-catalyzed selective hydroxylfluorination of gem-difluoroalkenes has been developed. By employing easily obtainable gem-difluoroalkenes and NFSI as the fluorine source, the scope, advantages, and limitations of this reaction were investigated. The reaction presents an efficient synthesis to afford a series of α-trifluoromethyl alcohols in good to excellent yields. Furthermore, this reaction probably proceeds via oxidation of Pd0 to PdII fluoride complex by NFSI, followed by fluoropalladation of gem-difluoroalkenes to generate an α-trifluoromethylbenzyl–Pd intermediate. And this strategy offers more possibilities for the construction of other bonds, such as C–C, C–N and C–S.

NHC-Copper(I) Halide-Catalyzed Direct Alkynylation of Trifluoromethyl Ketones on Water

Czerwiński, Pawe?,Molga, Edyta,Cavallo, Luigi,Poater, Albert,Michalak, Micha?

supporting information, p. 8089 - 8094 (2016/06/13)

An efficient and easily scalable NHC-copper(I) halide-catalyzed addition of terminal alkynes to 1,1,1-trifluoromethyl ketones, carried out on water for the first time, is reported. A series of addition reactions were performed with as little as 0.1-2.0?mo

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