185760-64-9

Upstream product

• 185760-61-6 1-(2-Methoxy-phenyl)-8-phenylsulfanyl-octan-4-one 
• 185760-60-5 1-(2-Methoxy-phenyl)-8-phenylsulfanyl-octan-4-ol 
• 185760-57-0 1-(2-Methoxy-phenyl)-4-phenylsulfanyl-butan-1-ol 
• 185760-62-7 8-(2-Methoxy-phenyl)-5-oxo-octanal 
• 185760-58-1 1-(2'-methoxyphenyl)-4-(phenylthio)butane 
• 185760-59-2 4-(2-methoxyphenyl)butanal 
• 135-02-4 ortho-anisaldehyde 
• 36449-75-9 1-(2-bromoethyl)-2-methoxybenzene 
• 185760-63-8 2-[2-(2'-methoxyphenyl)-ethyl]-2-cyclohexen-1-one 

Relevant academic research and scientific papers

Preparation of cis-5-methoxy-and-7-methoxy-1-acetoxy-1,2,3,4,4a,10a- hexahydro-9(10H)-phenanthrenone. An epoxide-arene reaction involving a selective 1,2-alkyl shift rearrangement

The preparation of cis-1α-acetoxy-7-methoxy-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrenone 5 was accomplished starting from 6-methoxy-1-tetralone. Reduction of 7-methoxy-1,2,3, 4,9,10-hexahydro-1-oxo-phenanthrene 8, acetylation and subsequent oxidation delivered 5, Application of an analogus procedure to the preparation of cis-1β-acetoxy-5-methoxy-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrenone 6 was not feasible. A more elaborate route was developed for the synthesis of compound 6, where an epoxide-arene reaction involving a 1,2-alkyl shift rearrangement, constituted a highly selective key transformation.