185799-74-0Relevant academic research and scientific papers
Small peptidic aldehyde inhibitors of human rhinovirus 3C protease
Shepherd, Timothy A.,Cox, Gregory A.,McKinney, Emma,Tang, Joseph,Wakulchik, Mark,Zimmerman, Ronald E.,Villarreal, Elcira C.
, p. 2893 - 2896 (1996)
Small peptide aldehydes were designed to mimic the preferred substrate requirements for the human rhinovirus 3C protease. Di- and tripeptide aldehydes containing a methionine sulfone as a P1 surrogate for glutamine show low micromolar enzyme inhibitory and antiviral tissue culture activity. LY338387, obtained in a short and efficient synthesis, appears to validate the protease as a therapeutic target.
