185799-93-3

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 80971-33-1 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine 

Downstream Products

• 185799-94-4 Acetic acid (2R,3S,5R)-5-(3-benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches. This journal is

The synthesis and hybridization properties of an oligonucleotide containing hexafluoroacetone ketal internucleotide linkages

The hexafluoroketal functionality is isosteric with the phosphate linkage in DNA and RNA. A thymidine:thymidine dimer bearing a hexfluoroacetone ketal internucleolide linkage has been synthesized from hexafluoroacetone using a Mitsunobu reaction. The resulting dimer has been incorporated into an oligonucleotide and has been shown to result in poorer binding to a complementary DNA and RNA relative to an unmodified control.