185799-94-4Relevant academic research and scientific papers
The synthesis and hybridization properties of an oligonucleotide containing hexafluoroacetone ketal internucleotide linkages
Lin, Kuei-Ying,Matteucci, Mark D.
, p. 8667 - 8670 (1996)
The hexafluoroketal functionality is isosteric with the phosphate linkage in DNA and RNA. A thymidine:thymidine dimer bearing a hexfluoroacetone ketal internucleolide linkage has been synthesized from hexafluoroacetone using a Mitsunobu reaction. The resulting dimer has been incorporated into an oligonucleotide and has been shown to result in poorer binding to a complementary DNA and RNA relative to an unmodified control.
