185815-66-1

Basic information

• Product Name: Cyclohexanamine, 4-(fluoromethyl)-, cis-
• CAS NO: 185815-66-1
• Molecular Formula: C7H14FN
• Molecular Weight: 131.193
• Mol File: 185815-66-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanamine, 4-(fluoromethyl)-, cis-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanamine, 4-(fluoromethyl)-, cis-(185815-66-1)
• EPA Substance Registry System: Cyclohexanamine, 4-(fluoromethyl)-, cis-(185815-66-1)

Safety Data

• Hazardous Substances Data: 185815-66-1(Hazardous Substances Data)

Upstream product

• 185815-67-2 2,2,2-Trifluoro-N-(4-hydroxymethyl-cyclohexyl)-acetamide 
• 61367-22-4 ((cis)-4-aminocyclohexyl)methanol hydrochloride 
• 223131-25-7 ((1S,4S)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzenesulfonate 
• 223131-01-9 tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate 
• 30134-98-6 ((1r,4r)-4-aminocyclohexyl)methanol 
• 223131-33-7 N-[cis-4-(fluoromethyl)cyclohexyl]-O-t-butylcarbamate 

Downstream Products

• 223131-45-1 1-fluoromethyl-4-isothiocyanato-cyclohexane 

Relevant articles and documents

Synthesis, radiosynthesis and biodistribution of N-(cis-4-[18F]fluoromethylcyclohexyl)-4-(1(H)-imidazol-4-yl)piperidine-1 -thiocarbonamide ([18F]VUF 5000), for evaluation as a potential PET ligand for the histamine H3 receptor

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Approaches towards the synthesis of fluoro(cyclo)alkylamines

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.