30134-98-6

Usage

Uses

Used in Pharmaceutical Industry:
(cis-4-Aminocyclohexyl)methanol is utilized as a chiral building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In agrochemicals, (cis-4-Aminocyclohexyl)methanol serves as a key intermediate in the production of biologically active compounds, enhancing crop protection and yield.
Used in Surfactant Production:
(cis-4-Aminocyclohexyl)methanol is employed as a raw material in the manufacturing of surfactants, which are essential in a wide range of applications including detergents, emulsifiers, and dispersants.
Used in Corrosion Inhibitor Production:
(cis-4-Aminocyclohexyl)methanol is also used as a component in the formulation of corrosion inhibitors, which are vital for protecting metal surfaces from degradation in various industrial settings.
Used in Specialty Chemicals:
(cis-4-Aminocyclohexyl)methanol finds application in the production of specialty chemicals, where its unique properties are leveraged to create high-value products for niche markets.

Upstream product

• 60601-15-2 4-Benzoylamino-cyclohexanecarboxylic acid ethyl ester 
• 150-13-0 4-amino-benzoic acid 
• 61367-16-6 cis-4-aminocyclohexanecarboxylic acid methyl ester hydrochloride 
• 3306-69-2 2-aza-bicyclo[2.2.2]octan-3-one 
• 60601-18-5 cis 4-benzoylaminocyclohexanemethanol 

Downstream Products

• 223131-01-9 tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate 
• 185815-66-1 cis-4-fluoromethylcyclohexylamine 
• 223131-45-1 1-fluoromethyl-4-isothiocyanato-cyclohexane 
• 223131-33-7 N-[cis-4-(fluoromethyl)cyclohexyl]-O-t-butylcarbamate 
• 223131-25-7 ((1S,4S)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzenesulfonate 
• 947141-76-6 ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate 
• 1417615-39-4 C₂₀H₂₆ClN₃O₃ 
• 1272670-06-0 5-(3-(7-oxabtcyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1S,4S)-4-(aminomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1272667-52-3 5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-7-((1s,4s)-4-(azidomethyl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1272667-53-4 ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methyl methanesulfonate 
• 1272667-38-5 (1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanecarbaldehyde 
• 1272667-39-6 ((1S,4S)-4-(5-(3-(7-oxabicyclo[2.2.1]heptan-1-ylmethoxy)phenyl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)methanol 

Relevant academic research and scientific papers

Approaches towards the synthesis of fluoro(cyclo)alkylamines

The synthesis of fluoro(cyclo)alkylamines 1-amino-6-fluorohexane (1), 1-amino-7-fluoroheptane (2), cis/trans-4-fluorocyclohexylamine (3a,b) and cis-4-fluoromethylcyclohexylamine (4) has been investigated for use as synthons for histamine receptor ligands for use in PET.

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.