18583-55-6

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chlorobenzyl)triphenylphosphonium Chloride Hydrate is used as a reagent for the synthesis of various pharmaceutical compounds, particularly in the Wittig reaction with imidazolecarboxaldehyde to produce level 4-(5)arylethenylimidazoles. These synthesized compounds have potential applications in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, (2-Chlorobenzyl)triphenylphosphonium Chloride Hydrate is used as a versatile reagent for the preparation of a wide range of organic compounds, including alkenes, which are essential building blocks in the synthesis of various chemicals, materials, and pharmaceuticals.
Used in Research and Development:
(2-Chlorobenzyl)triphenylphosphonium Chloride Hydrate is also utilized in research and development laboratories for the exploration of new synthetic pathways and the development of innovative chemical processes. Its application in the Wittig reaction allows researchers to access a diverse array of alkenes, which can be further modified and functionalized to create novel compounds with potential applications in various industries.

InChI:InChI=1/C25H21ClP.ClH/c26-25-19-11-10-12-21(25)20-27(22-13-4-1-5-14-22,23-15-6-2-7-16-23)24-17-8-3-9-18-24;/h1-19H,20H2;1H/q+1;/p-1

Upstream product

• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 603-35-0 triphenylphosphine 

Downstream Products

• 869106-77-4 2-[2-(2-chlorophenyl)vinyl]-1-(3-methoxypropyl)-1H-pyrrole 
• 869106-82-1 5-[2-(2-chlorophenyl)vinyl]-1-(3-methoxypropyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 112704-51-5 E-2-(4-fluorophenyl)-3-(2-chlorophenyl)-propenal 
• 85676-74-0 (E)-1-chloro-2-(4-methoxystyryl)benzene 
• 25144-38-1 (E)-2,2'-dichlorostilbene 
• 20657-43-6 (Z)-1,2-bis(2-chlorophenyl)ethene 
• 908863-91-2 (E)-2-[2-(2-chlorophenyl)ethenyl]-5-methoxy-1H-indole 
• 75961-25-0 5-[(Z)-2-(2-Chloro-phenyl)-vinyl]-1H-imidazole 

Relevant academic research and scientific papers

Chiral Imidodiphosphoric Acid-Catalyzed Highly Diastereo- and Enantioselective Synthesis of Poly-Substituted 3,4-Dihydro-2 H-pyrans: [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketoesters and 3-Vinylindoles

Imidodiphosphoric acids were employed to catalyze inverse-electron-demand hetero-Diels-Alder reaction of β,γ-unsaturated α-ketoesters and 3-vinylindoles. A series of optically active 3,4-dihydro-2H-pyran derivatives with three contiguous stereogenic centers was synthesized in excellent yields (70-99%), diastereoselectivities (>20:1), and enantioselectivities (73-99%). The resulting indole containing 3,4-dihydro-2H-pyran could be converted to tetrahydropyran derivatives, which appear in several biological active compounds by simple hydrogenation reduction.

Inhibitors of checkpoint kinases (Wee1 and Chk1)

This invention relates to substituted indacene molecules that specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 and are useful in the treatment of proliferative disorders.

Kinetic Study of the Substitution Reactions of Triphenylphosphine with Chlorobenzyl Chlorides, Dimethylbenzyl Chloride, and Methylbenzyl Bromides in Various Two-Phase Organic Solvent/Water Media

The kinetics of the substitution reactions of triphenylphosphine (TP) with chlorobenzyl chlorides (CBC), 2,5-dimethylbenzyl chloride (DMBC), and methylbenzyl bromides (MBB) in aprotic organic solvent was studied under the extraction by water. The effects of water, agitation, organic solvent, reactant, and temperature were investigated. These reactions take place via the SN2 mechanism and exhibit large and negative entropy of activation. The order of relative activity of solvents is CHCl3 > CH2Cl2 >> C6H6. In CHCl3, the order of relative reactivity of benzyl chloride (BC), benzyl bromide (BB), CBC, DMBC, and MBB toward reaction with TP is 2-MBB > 4-MBB > 3-MBB > BB > DMBC > BC > 2-CBC > 4-CBC > 3-CBC. These reactions produce quantitatively benzyltriphenylphosphonium salts, which are useful for synthesizing Z-form isomers of stilbenes via the two-phase Wittig reaction.

Synthesis and Photocylization of some 4-(5)Arylethenylimidazoles

The synthesis of eleven 4-(5)arylethenylimidazoles and their separation into cis and trans isomers is described.Ir, uv, nmr, and mass spectrometric data of the compounds are given.The photocyclization of the unsubstituted and p-substituted compounds is reported.