185836-40-2Relevant academic research and scientific papers
“In-loop” [11C]CO2 fixation: Prototype and proof of concept
Dahl, Kenneth,Collier, Thomas L.,Cheng, Ran,Zhang, Xiaofei,Sadovski, Oleg,Liang, Steven H.,Vasdev, Neil
, p. 252 - 262 (2018)
Carbon-11-labeled carbon dioxide is the most common feedstock for the synthesis of positron emission tomography radiotracers and can be directly used for 11C-carbonylation. Herein, we report the development of an apparatus that takes advantage of “in-loop” technologies to facilitate robust and reproducible syntheses of 11C-carbonyl-based radiotracers by [11C]CO2-fixation. Our “in-loop” [11C]CO2-fixation method is simple, efficient, and proceeds smoothly at ambient pressure and temperature. We selected model 11C-carbonyl-labeled carbamates as well as symmetrical and unsymmetrical ureas based on their widespread use in radiotracer design and our clinical research interests for proof of concept. Utility of this method is demonstrated by the synthesis of a reversible radiopharmaceutical for monoamine oxidase B, [11C]SL25.1188, and 2 novel fatty acid amide hydrolase inhibitors. These radiotracers were isolated and formulated (>3.5?GBq; 100?mCi) with radiochemical purities (>99%) and molar radioactivity (≥80?GBq/μmol; ≥2162?mCi/μmol).
Oxazolidinone derivatives, their preparation and therapeutical use
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, (2008/06/13)
The present invention relates to isoindole derivatives, and more particularly to 5-(hydroxymethyl)oxazolidine-2-one derivatives which are substituted at the 3 position by an indazole, benzisoxazole or benzisothiazole ring system, to a process for their pr
