185909-33-5Relevant academic research and scientific papers
Synthesis of pure enantiomers of cis-and trans-3-(trifluoromethyl) pyroglutamic esters
Gestmann, Detlef,Laurent, Andre J.,Laurent, Eliane G.
, p. 27 - 30 (1996)
The addition of the racemic Schiff base ethyl N-(diphenylmethylene)glycinate (2), from glycine ester, to ethyl-4,4,4-trifluorocrotonate gives, according to the experimental conditions, one or two Michael adducts. Acidic hydrolysis gives the cis/trans-3-(t
Synthesis, enzymatic resolution and absolute configuration of ethyl trans-3-(trifluoromethyl)pyroglutamate
Antolini, Luciano,Forni, Arrigo,Moretti, Irene,Prati, Fabio,Laurent, Eliane,Gestmann, Detlef
, p. 3309 - 3314 (1996)
Ethyl trans-3-(trifluoromethyl)pyroglutamate 1 is synthesized in excellent yield; racemic 1 is enzymatically resolved with α-chymotrypsin-catalyzed hydrolysis affording both the enantiomerically pure enantiomers. The absolute configuration is established
Bicyclic-Fused Heteroaryl or Aryl Compounds
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Paragraph 0747, (2015/10/28)
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
