18593-18-5Relevant academic research and scientific papers
Dynamic Kinetic Resolution of Phosphinic Acid Derivatives via Nucleophilic Substitution at Phosphorus Center
Strzelecka, Dorota,Baok, Olga,Borowski, Piotr,Stankevi?, Marek
, p. 4922 - 4932 (2018/12/14)
Reaction of racemic phosphinic acid derivatives with chiral alcohols proceeds with predominant formation of one diastereomer. The highest level of enrichment has been obtained for transesterfication of racemic methyl benzylphenylphosphinate (64% de). The
Directed ortho-lithiation of unprotected diphenylphosphinic acids
Ya?ez Rodríguez, Víctor,Del águila, Miguel ángel,Iglesias, María José,López Ortiz, Fernando
experimental part, p. 7355 - 7362 (2012/09/22)
Directed ortho lithiation of diphenylphosphinic acid and subsequent electrophilic trapping provides mono ortho-functionalized derivatives including enantiopure γ-aminophosphinic acids in moderate yields. Copper catalyzed coupling of the ortho anion leads to biphenyl-2,2′- diylbis(phenylphosphinic acid), a phosphorus analogue of biphenyl-2,2′- dicarboxylic acid. Preliminary studies of the metal-binding abilities of this O,O-chelating ligand towards a series of metal cations are included.
Synthesis of Novel Phosphorus Heterocycles: 1,3-Dihydro-2,1-Benzoxaphosphole 1-Oxides
Miles, J. A.,Grabiak, R. C.,Cummins, C.
, p. 1677 - 1682 (2007/10/02)
A class of novel phosphorus heterocycles, 1,3-dihydro-2,1-benzoxaphosphole 1-oxides, has been prepared by two different routes.One general approach involves the cyclization of ortho-substituted phenylphosphinic acid derivatives under either thermal or sol
SYNTHESIS, REACTIVITY AND CONFORMATION OF 10,11-DIHYDRODIBENZO-PHOSPHEPIN AND DIBENZOPHOSPHEPIN DERIVATIVES. PHOSPHORUS ANALOGUES OF IMINOBIBENZYL ANTIDEPRESSANTS
Segall, Yoffi,Shirin, Ezra,Granoth, Itshak
, p. 243 - 254 (2007/10/02)
Derivatives of the novel dibenzophosphepin system are prepared from 10,11-dihydro-5-phenyl-5H-bibenzophosphepin 5-oxide (2).New members in the 10,11-dihydro-5H-dibenzophophepin series, including phosphorus analogues (7, 10) of the antidepressant drug imipramine (30), are also reported.Products of the nucleophilic substitution at tetrahedral phosphorus in 2 appear to be determined by the relative apicophilicity of the nucleophile.Conformational analysis based on 1H NMR data suggests folded ("butterfly") conformation for the tricyclic compounds.The twisted boat conformation of the central ring in the 10,11-dihydro compounds bears a pseudo-equatorial P=O oxygen or a P=S sulfur, in solution.Symmetric AA'BB' spin systems are found in 4, 5 and 7, and their solution conformations appear to be similar to those of analogous 10,11-dihydrodibenzoazepine derivatives.The interaction of some compounds with NMR shift reagents and their mass spectral fragmentations are discussed.
