1859379-85-3

Basic information

• Product Name: Propargyl-PEG2-acid
• Synonyms: Propargyl-PEG2-acid;Propyne-PEG1-CH2CH2COOH;3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid;Propargyl-PEG1-COOH
• CAS NO: 1859379-85-3
• Molecular Formula: C8H12O4
• Molecular Weight: 172.18
• Mol File: 1859379-85-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: Propargyl-PEG2-acid(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl-PEG2-acid(1859379-85-3)
• EPA Substance Registry System: Propargyl-PEG2-acid(1859379-85-3)

Safety Data

• Hazardous Substances Data: 1859379-85-3(Hazardous Substances Data)

Usage

Description

Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker that features a carboxylic acid at one end and a propargyl group at the other. This unique structure allows for versatile applications in chemical biology and medicinal chemistry. The carboxylic acid can react with primary amines to form stable amide bonds, while the propargyl group can react with azide-containing compounds to create a stable triazole linkage through click chemistry. The hydrophilic PEG linker enhances solubility in biological applications, making Propargyl-PEG2-acid a valuable tool for bioconjugation and the synthesis of small molecules, conjugates, and other compounds.

Uses

Used in Chemical Biology and Medicinal Chemistry:
Propargyl-PEG2-acid is used as a heterobifunctional crosslinker for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, and other tool compounds. Its dual functional groups enable the formation of stable amide and triazole linkages, making it a versatile building block in chemical biology and medicinal chemistry.
Used in Bioconjugation:
Propargyl-PEG2-acid is used as a linker in bioconjugation, allowing for the stable attachment of biomolecules through the formation of amide bonds with primary amines and triazole linkages with azide-containing compounds.
Used in Drug Delivery Systems:
Propargyl-PEG2-acid can be used as a component in the development of drug delivery systems, such as antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation. Its hydrophilic PEG linker improves solubility and bioavailability, potentially enhancing the therapeutic outcomes of these systems.
Used in Targeted Protein Degradation:
Propargyl-PEG2-acid is used as a building block in the synthesis of proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation. Its unique structure allows for the creation of molecules that can selectively degrade specific proteins, potentially leading to novel therapeutic strategies for various diseases.