185965-96-2Relevant academic research and scientific papers
Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates
Ivanova, Maria V.,Besset, Tatiana,Pannecoucke, Xavier,Poisson, Thomas
, p. 778 - 784 (2017/12/06)
We report the palladium-catalyzed introduction of the difluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF 2 PO(OEt) 2 species generated in situ, the method allows the functionalization
Copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates: A new method for aryldifluorophosphonates
Jiang, Xueliang,Chu, Lingling,Qing, Feng-Ling
, p. 1736 - 1741 (2013/06/27)
An unprecedented copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates has been developed, allowing rapid access to a wide range of aryldifluorophosphonates containing various functional groups. This method provides a complementary and alternative method to Cu-mediated cross-couplings of aryl iodides with metalated difluoromethylphosphonates.
