185968-90-5 Usage
General Description
Z-D-DAP(FMOC)-OH is a chemical compound that consists of a dipeptide (Z-D-DAP) with a fluorescent tag (FMOC) and a carboxylic acid group (OH). The dipeptide Z-D-DAP, also known as benzyl 2,6-diaminopimelate, is a synthetic derivative of the bacterial cell wall component diaminopimelic acid (DAP). The FMOC tag is commonly used as a fluorescent labeling reagent in chemical and biological research. The carboxylic acid group provides the compound with potential for further chemical modification and conjugation to other molecules. Z-D-DAP(FMOC)-OH may find applications as a building block in the synthesis of peptide-based compounds and as a tool for studying bacterial cell wall biosynthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 185968-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,9,6 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 185968-90:
(8*1)+(7*8)+(6*5)+(5*9)+(4*6)+(3*8)+(2*9)+(1*0)=205
205 % 10 = 5
So 185968-90-5 is a valid CAS Registry Number.
185968-90-5Relevant articles and documents
Total synthesis of quinaldopeptin and its analogues
Ichikawa, Satoshi,Okamura, Takuya,Matsuda, Akira
, p. 12662 - 12670 (2013)
The first total synthesis of quinaldopeptin (1) was accomplished. Our approach to the synthesis of 1 includes the solid-phase peptide synthesis of the linear decapeptide 4 followed by macrocyclization and introduction of the quinoline chromophores 2 at a late stage of the synthesis. As for the preparation of 4, a fragment coupling approach was applied considering the C2 symmetrical structure of 1. Chromophore analogues 22 and 23 and desmethyl analogue 27 were also prepared in a manner similar to the synthesis of 1. Synthetic 1 exhibits a strong cytotoxicity with the IC50 value of 3.2 nM. On the other hand, the activity of 23 and 27 was largely reduced.
