185990-36-7Relevant academic research and scientific papers
SILVER-CATALYZED SYNTHESIS OF AMIDES FROM AMINES AND ALDEHYDES
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Page/Page column 11-12, (2011/08/08)
The invention provides a method for producing amides via the reaction of aldehydes and amines with oxygen adsorbed on a metallic silver or silver alloy catalyst. An exemplary reaction is shown in Scheme 1 : (I), (II), (III)
Highly selective acylation of dimethylamine mediated by oxygen atoms on metallic gold surfaces
Xu, Bingjun,Zhou, Ling,Madix, Robert J.,Friend, Cynthia M.
body text, p. 394 - 398 (2010/04/02)
"Chemical Equation Presented" Completely coupled: The acylation of dimethylamine through coupling to formaldehyde occurs with almost 100 % selectivity at low coverage of adsorbed O atoms on metallic gold and with a low activation energy. Oxygen creates an active intermediate (CH3) 2N(a), which attacks the carbonyl carbon of the aldehyde (see picture). A general mechanistic framework for efficient and selective acylation of amines promoted by Au is established.
