186036-97-5Relevant academic research and scientific papers
Synthesis of carboranyl polyamines for DNA targeting
Cai, Jianping,Soloway, Albert H.
, p. 9283 - 9286 (1996)
Three groups of internal and terminal N-substituted carboranyl spermidines/spermines were synthesized as potential BNCT agents for the treatment of malignant tumors.
Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: Synthesis and biological evaluation
Cai, Jianping,Soloway, Albert H.,Barth, Rolf F.,Adams, Dianne M.,Hariharan, Joya R.,Wyzlic, Iwona M.,Radcliffe, Krista
, p. 3887 - 3896 (2007/10/03)
Three series of new boron-containing spermidine/spermine (SPD/SPM) analogues have been synthesized: N1- and N5-(4-carboranylbutyl) SPD/SPM derivatives (SPD-1, SPD-5, SPM-1, SPM-5); N1,N10-diethyl-N5-(4- carboranylbutyl)spermidine (DESPD-5), N1-N14-diethyl-N5-(4- carboranylbutyl)spermine (DESPM-5); and N5,N10-bis(4- carboranylbutyl)spermine (SPM-5, 10). In vitro studies using rat F98 glioma cells have shown that these polyamines retain the ability to displace ethidium bromide from calf thymus DNA and are rapidly taken up by F98 glioma cells. However, their cytotoxicities, especially these with terminal N- substituted (SPD-1, SPM-1) boron compounds, are greater than those of SPD/SPM. Nevertheless, the groundwork has been created for a new class of boron-containing compounds that maybe useful for boron neutron capture therapy of tumors.
