18609-16-0 Usage
Description
DESACETYLNIMBIN, also known as a new limonoid, is a chemical compound derived from the nimbin molecule, in which the acetyloxy group at position 6 is replaced by a hydroxy group. It has been isolated from Azadirachta indica and is characterized by its white solid appearance. DESACETYLNIMBIN is a promising pharmaceutical candidate due to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
DESACETYLNIMBIN is used as an active pharmaceutical ingredient for its potential antitumor properties. It is derived from Arisaema decipiens, a traditional antitumor herb, and may exhibit similar therapeutic effects.
Used in Drug Development:
DESACETYLNIMBIN is used as a lead compound in drug development, particularly for the development of novel anticancer agents. Its unique chemical structure and potential antitumor properties make it a valuable candidate for further research and development.
Used in Chemical Research:
DESACETYLNIMBIN is used as a subject of study in chemical research, allowing scientists to explore its properties, interactions, and potential applications in various fields, including pharmaceuticals, materials science, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 18609-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,0 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18609-16:
(7*1)+(6*8)+(5*6)+(4*0)+(3*9)+(2*1)+(1*6)=120
120 % 10 = 0
So 18609-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C28H34O8/c1-14-16(15-8-10-35-13-15)11-17-21(14)28(4)18(12-20(30)33-5)27(3)19(29)7-9-26(2,25(32)34-6)23(27)22(31)24(28)36-17/h7-10,13,16-18,22-24,31H,11-12H2,1-6H3
18609-16-0Relevant articles and documents
Structural flexibility in the biocatalyst-mediated functionalization of ring 'A' in salannin, a tetranortriterpene from Azadirachta indica
Madyastha, K. Madhava,Venkatakrishnan, Krishnamachari
, p. 3055 - 3062 (2000)
Nocardia sp. quantitatively converts salannin 1 and 3-de-O-acetylsalannin 2 (C-seco limonoids) into 3-deacetoxy1-de[(E)-2-methylbut-2-enoyloxy]salannin-1-en-3-one 10, a novel and potentially bioactive compound with an α,β-unsaturated ketone moiety in ring 'A'. In order to establish the sequence of events involved in this transformation and the structural specificity of this bacterial system, several new derivatives of salannin 1 have been prepared. These studies have indicated that the transformation is initiated by deacetylation at C-3, followed by oxidation of the secondary hydroxy group to 3-keto, which appears to facilitate the elimination of the tigloyloxy/acetoxy group at C-l with the formation of an olefinic linkage between C-l and C-2. The organism very efficiently transforms some of the derivatives of salannin into their corresponding compounds possessing an enone system in ring 'A', an essential pre-requisite for various biological activities. Some of the C-seco limonoids prepared in the present study, viz. 10, 1,2-didehydro-1,3-dideoxy-3-oxosalannic acid 18, 3-deacetoxy-1-de[(E)-2-methylbut-2-enoyloxy]-20,21,22,23-tetrahydrosalannin-1- en-3-one 15 and 1,2-didehydro-1,3-dideoxy-3-oxosalannol 23 were hitherto not known. The Royal Society of Chemistry 2000.
