18614-54-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Methoxy-4-nitropyridine is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs. Its unique chemical structure allows it to be a versatile component in the creation of various medicinal compounds.
Used in Organic Chemical Synthesis:
In the realm of organic chemistry, 2-Methoxy-4-nitropyridine serves as an intermediate for synthesizing other organic chemicals. Its reactivity and functional groups make it a valuable precursor for a range of chemical products.
Used in Research and Development Studies:
2-Methoxy-4-nitropyridine is also employed in research and development settings. It is used to explore new chemical reactions, understand reaction mechanisms, and develop innovative applications in both academic and industrial research.
Used in Chemical Reactions as a Building Block:
Due to its strong nitro and methoxy substituents, 2-Methoxy-4-nitropyridine is a useful building block for various chemical reactions. Its presence can influence the properties and reactivity of the compounds it is part of, making it an important component in the synthesis of complex organic molecules.

Upstream product

• 20773-98-2 2-methoxypyridine N-oxide 
• 4487-51-8 4-Nitro-2-hydroxy-pyridin 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Microwave-assisted silver(I)-mediated selective O-alkylation of aromatic imidate systems

A novel microwave-assisted protocol has been developed for the selective O-alkylation of aromatic imidate systems with various halides under microwave irradiation using silver carbonate as the base. Products were obtained in short reaction time and in excellent yields. Georg Thieme Verlag Stuttgart.

Design of thymidylate synthase inhibitors using protein crystal structures: The synthesis and biological evaluation of a novel class of 5- substituted quinazolinones

The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out by a repetitive crystallographic analysis of protein-ligand structures. At the onset of this project, we focused on the folate cofactor binding site of a high-resolution ternary crystal complex of Escherichia coli TS, 5'-fluorodeoxyuridylate (5-FdUMP) and a classical glutamate-containing folic acid analog. A preliminary ternary crystal structure of a novel compound was successfully solved. Upon analysis of this initial complex, further structural elaborations were made, and a series of active 5- (arylthio)quinazolinones was developed. The synthetic strategy was based on the displacement of a halogen at the 5-position of a quinazolinone by various arylthioanions. The compounds were tested for inhibition of purified E. coli and/or human TS, and were assayed for cytotoxicity against three tumor cell lines in vitro. Significant thymidine protection effects were observed with several of the inhibitors, indicating that TS was the intracellular locus of activity.