18616-08-5Relevant academic research and scientific papers
Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase
Vandyck, Koen,Cummings, Maxwell D.,Nyanguile, Origène,Boutton, Carlo W.,Vendeville, Sandrine,McGowan, David,Devogelaere, Benoit,Amssoms, Katie,Last, Stefaan,Rombauts, Klara,Tahri, Abdellah,Lory, Pedro,Hu, Lili,Beauchamp, Derek A.,Simmen, Kenny,Raboisson, Pierre
scheme or table, p. 4099 - 4102 (2010/02/28)
HCV NS5B polymerase, an essential and virus-specific enzyme, is an important target for drug discovery. Using structure-based design, we optimized a 1,5-benzodiazepine NS5B polymerase inhibitor chemotype into a new sulfone-containing scaffold. The design
