186179-28-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 186179-27-1 tert-butyl N-(4-aminobutyl)-N-(3-hydroxypropyl)dicarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 68076-36-8 1-amino-4-[(tert-butyloxycarbonyl)amino]butane 
• 186179-25-9 Acetic acid 3-[(4-tert-butoxycarbonylamino-butyl)-(toluene-4-sulfonyl)-amino]-propyl ester 
• 186179-26-0 {4-[(3-Hydroxy-propyl)-(toluene-4-sulfonyl)-amino]-butyl}-carbamic acid tert-butyl ester 
• 186179-24-8 1,1-dimethylethyl {4-{[(4-methylphenyl)sulfonyl]amino}butyl}carbamate 
• 164365-89-3 N-<4-<(tert-butoxycarbonyl)amino>butyl>-N-(3-hydroxypropyl)amine 

Relevant academic research and scientific papers

178. Electrospray-ionization mass spectrometry part III: Acid-catalyzed isomerization of N,N′-bis[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]spermidines by the Zip reaction

The electrospray tandem mass spectra (ESI-MS/MS) of the three N,N′-bis[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]spermidines 1-3 displayed the same fragment-ion signals. These isomers could not be differentiated by ESI-MS/MS, since their fragmentation patterns are similar. (E,E)-N-(3-[ 15N]Aminopropyl)-3,3′-bis(4-hydroxyphenyl)-N,N′-(butane- 1,4-diyl)bis[prop-2-enamide] ([15N(1)]-1) was synthesized in order to get further information about the fragmentation mechanisms. The comparison of the ESI-MS/MS of 1 and [15N(1)]-1 revealed a transamidation, the Zip reaction, under mass-spectral conditions of the [1 + H]+ ions. Because of this reaction, the three isomers 1-3 could not be distinguished.