186193-23-7

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 162599-95-3 (R)-3-(3-Chloro-4-methoxy-phenyl)-2-((2E,7E)-(5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-propionic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 204376-49-8 (S)-2-Amino-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 204376-54-5 (E)-(6S,9S,15R)-15-(3-Chloro-4-methoxy-benzyl)-6-isobutyl-9-((E)-(R)-1-methyl-3-phenyl-allyl)-8-oxa-5,14,17-triaza-spiro[2.15]octadec-11-ene-4,7,13,16-tetraone 
• 204376-52-3 (S)-2-[(1-Aminomethyl-cyclopropanecarbonyl)-amino]-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 204376-51-2 (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region)

Analogs of the antitumor agents cryptophycins 1 and 8 with dialkyl substitution at C-6 (fragment C) were synthesized and evaluated for in vitro cytotoxicity against human leukemia cells (CCRF-CEM). The activity of these analogs decreased as the size of the substituents at C-6 increased. The C-6 spirocylopropyl compound (2g) was highly potent in vitro and showed excellent antitumor activity in animal models.