2320-06-1

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1-phenylethyl)-4-(propan-2-yl)benzene is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of novel treatments for different health conditions.
Used in Organic Material Production:
In the field of organic materials, 1-(1-phenylethyl)-4-(propan-2-yl)benzene serves as a crucial building block. Its incorporation into the production process leads to the creation of advanced materials with specific properties, such as improved stability, reactivity, or functionality, which can be applied in various industrial applications.
Used in Medicinal Chemistry and Drug Discovery Research:
Due to its potential biological activities, 1-(1-phenylethyl)-4-(propan-2-yl)benzene is an important target in medicinal chemistry and drug discovery research. Scientists and researchers utilize its properties to explore new therapeutic avenues and develop innovative drugs with enhanced efficacy and safety profiles.

Upstream product

• 18620-03-6 4-isopropylphenylmagnesium bromide 
• 98-86-2 acetophenone 
• 100-42-5 styrene 
• 1037062-66-0 2-(4-isopropylphenyl)-[1,3,2]-dioxaborolane 
• 98-82-8 Isopropylbenzene 
• 98-85-1 1-Phenylethanol 

Downstream Products

• 107923-15-9 1-(4-isopropyl-phenyl)-1-phenyl-ethyl hydroperoxide 

Relevant academic research and scientific papers

Synthesis of diarylmethanes via a Friedel-Crafts benzylation using arenes and benzyl alcohols in the presence of triphenylphosphine ditriflate

Triphenylphosphine ditriflate (TPPD) was found to be an efficient promoter for the Friedel-Crafts benzylation of arenes with benzyl alcohols in CH 2Cl2 at room temperature. The good yields, the 1:1 molar ratio of arene and benzyl alcohol, the benzylation of chlorobenzene as a nonactivated aromatic compound at room temperature, and no by-product formation are the main advantages of this procedure.

Alkene Hydrofunctionalization Reactions

A reductive cross coupling reaction process for functionalization of a nucleophilic alkene can be achieved. The nucleophilic alkene and a nucleophilic cross coupling partner compound can be reacted in the presence of an oxidizable alcohol and a suitable catalyst to form a reductive coupling product. Various additives can also be useful to refine the process such as by mitigating certain undesirable intermediates, facilitating specific site selectivity for various substitutions or reaction sites, etc. Chiral additives can be optionally used which act to provide asymmetric catalysis, e.g. allow for regioselective and stereoselective production of reductive coupling products. A reductive cross coupling pathway can include oxidizing the oxidizable alcohol to form a catalyst hydride. The nucleophilic alkene can be inserted into the catalyst hydride to form a catalyst-alkyl intermediate. Further, the catalyst-alkyl intermediate can be transmetallized with the nucleophilic cross coupling partner compound to form a transmetallated intermediate. The catalyst can be reductively eliminated to form the reductive coupling product and a reduced catalyst. Finally, the reduced catalyst can be oxidized under aerobic conditions, for example with oxygen, to form the oxidized catalyst and subsequent repetition through the cyclic pathway.

Aerobic alcohol oxidation coupled to palladium-catalyzed alkene hydroarylation with boronic esters

(Chemical Equation Presented) An oxidation exercise: An aerobic alcohol oxidation coupled with a regioselective palladium-catalyzed reductive functionalization of styrenes and arylboronic esters has been developed (see scheme). The mechanism is thought to proceed by initial oxidation of the solvent to generate a PdII-hydride species, which subsequently reacts with the alkene and arylboronic ester to ultimately generate a new C-C bond.