186203-16-7

Basic information

• Product Name: N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine
• Synonyms: N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine
• CAS NO: 186203-16-7
• Molecular Weight: 320.475
• Mol File: 186203-16-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine(186203-16-7)
• EPA Substance Registry System: N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine(186203-16-7)

Safety Data

• Hazardous Substances Data: 186203-16-7(Hazardous Substances Data)

Upstream product

• 104062-70-6 (S)-N-Boc-leucinal 
• 87-59-2 2,3-Dimethylaniline 
• 6404-28-0 Boc-Nle-OH 
• 104062-69-3 N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide 

Downstream Products

• 183500-17-6 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one 
• 1071154-09-0 5(S)-n-Butyl-1-(2,3-dimethylphenyl)-2-piperazinone 
• 247593-34-6 ((S)-1-{[(2-Chloro-acetyl)-(2,3-dimethyl-phenyl)-amino]-methyl}-pentyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase

The evaluation of SAR associated with the insertion of carbonyl groups at various positions of N-arylpiperazinone farnesyltransferase inhibitors is described herein. 1-Aryl-2,3-diketopiperazine derivatives exhibited the best balance of potency and pharmac

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras