183500-17-6

Basic information

• Product Name: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one
• Synonyms: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one
• CAS NO: 183500-17-6
• Molecular Weight: 360.497
• Mol File: 183500-17-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one(183500-17-6)
• EPA Substance Registry System: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one(183500-17-6)

Safety Data

• Hazardous Substances Data: 183500-17-6(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 186203-16-7 N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine 
• 87-59-2 2,3-Dimethylaniline 
• 104062-69-3 N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide 
• 6404-28-0 Boc-Nle-OH 
• 104062-70-6 (S)-N-Boc-leucinal 
• 247593-34-6 ((S)-1-{[(2-Chloro-acetyl)-(2,3-dimethyl-phenyl)-amino]-methyl}-pentyl)-carbamic acid tert-butyl ester 

Downstream Products

• 1071154-09-0 5(S)-n-Butyl-1-(2,3-dimethylphenyl)-2-piperazinone 

Relevant articles and documents

INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

The present invention is directed to compounds which inhibit prenyl-protein transferases, farnesyl-protein transferase and geranylgeranyl-protein transferase type I, and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I and the prenylation of the oncogene protein RAS.

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras