186293-55-0

Basic information

• Product Name: (S)-(4-benzylMorpholin-2-yl)MethanaMine
• Synonyms: (S)-(4-benzylMorpholin-2-yl)MethanaMine;[(2S)-4-benzylMorpholin-2-yl]MethanaMine;(2S)-4-(phenylMethyl)-2-MorpholineMethanaMine;(S)-2-(Aminomethyl)-4-benzylmorpholine
• CAS NO: 186293-55-0
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.28412
• Mol File: 186293-55-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-(4-benzylMorpholin-2-yl)MethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(4-benzylMorpholin-2-yl)MethanaMine(186293-55-0)
• EPA Substance Registry System: (S)-(4-benzylMorpholin-2-yl)MethanaMine(186293-55-0)

Safety Data

• Hazardous Substances Data: 186293-55-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(4-benzylMorpholin-2-yl)MethanaMine is used as a therapeutic agent for the treatment of psychiatric and neurological disorders such as schizophrenia and Parkinson's disease. Its antagonistic action on dopamine receptors helps in managing the symptoms associated with these conditions.
Used in Pain Management:
(S)-(4-benzylMorpholin-2-yl)MethanaMine is used as an analgesic agent, leveraging its interaction with dopamine receptors to provide pain relief, making it a potential candidate for the development of new pain management therapies.
Used in Antipsychotic Therapy:
(S)-(4-benzylMorpholin-2-yl)MethanaMine is used as an antipsychotic agent, where its ability to modulate dopamine receptor activity can contribute to the control of psychotic symptoms in patients with conditions such as schizophrenia.
These applications highlight the versatility of (S)-(4-benzylMorpholin-2-yl)MethanaMine in various areas of medicine, emphasizing its potential for further research and development to improve patient outcomes in the treatment of neurological and psychiatric conditions.

Upstream product

• 110859-47-7 (4-benzylmorpholin-2-yl)methanamine 
• 147767-51-9 4-benzyl-2-cyanomorpholine 

Downstream Products

• 1305117-36-5 N₄-{[(2S)-4-Benzylmorpholin-2-yl]methyl}-6-chloro-2-(trifluoromethyl)pyrimidine-4,5-diamine 
• 1305117-30-9 N₄-{[(2S)-4-benzylmorpholin-2-yl]methyl}-6-chloro-2-cyclopropylpyrimidine-4,5-diamine 
• 122894-38-6 (S)-4-benzyl-2-(N,N-dimethylaminomethyl)morpholine 
• 133762-22-8 (S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid 
• 214273-19-5 (R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine 

Relevant articles and documents

Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes

PDE8B is a cAMP-specific isoform of the broader class of phosphodiesterases (PDEs). As no selective PDE8B inhibitors had been reported, a high throughput screen was run with the goal of identifying selective tools for exploring the potential therapeutic utility of PDE8B inhibition. Of the numerous hits, one was particularly attractive since it was amenable to rapid deconstruction leading to inhibitors with very high ligand efficiency (LE) and lipophilic ligand efficiency (LLE). These triazolopyrimidines were optimized for potency, selectivity and ADME properties ultimately leading to compound 42. This compound was highly potent and selective with good bioavailability and advanced into pre-clinical development.

Prophylactic or therapeutic agent for diseases attributable to infection with helicobacters

The present invention relates to an agent for the prophylaxis and treatment of diseases caused by Helicobacter infections, which comprises (S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxyl

Synthesis and structure-activity relationships of 7-(2- aminoalkyl)morpholinoquinolones as anti-helicobacter pylori agents

A series of the titled compounds was synthesized and tested for anti- Helicobacter pylori activities. We discovered Y-34867 having the most potent activity against Helicobacter pylori among the quinolones tested along with high photostability. Furthermore