186347-65-9

Usage

Uses

Used in Pharmaceutical Research:
1-(3,4-difluoro-phenyl)-cyclopropanecarbonitrile is utilized as an intermediate in the synthesis of pharmaceuticals, leveraging its unique structure to create novel drug candidates. Its potential to exhibit interesting chemical and biological activities makes it a valuable compound for further exploration in drug discovery and development.
Used in Agrochemical Production:
In the agrochemical industry, 1-(3,4-difluoro-phenyl)-cyclopropanecarbonitrile serves as a building block for the creation of various agrochemicals. Its incorporation into these products can enhance their effectiveness in pest control and crop protection, contributing to improved agricultural yields.
Used in Medicinal Chemistry:
1-(3,4-difluoro-phenyl)-cyclopropanecarbonitrile is employed as a key component in the field of medicinal chemistry. Its unique properties allow for the design and development of new drugs with potential applications in treating various diseases and conditions.
Used in Drug Design:
1-(3,4-difluoro-phenyl)-cyclopropanecarbonitrile is also used in drug design, where its structural attributes can be manipulated to create innovative and effective pharmaceuticals. Its versatility in this context makes it an attractive option for researchers seeking to develop new therapeutic agents.

Upstream product

• 658-99-1 (3,4-difluorophenyl)acetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 186347-67-1 1-(3,4-difluorophenyl)cyclopropanecarboxylic acid 

Relevant academic research and scientific papers

Preparation method of arylcyclopropane compound

The present invention discloses a method for preparing an arylcyclopropane compound, 1.0eq phenylacetonitrile and 1.1eq 1-bromo-2-chloroethane as the starting material, N, N- dimethylacetamide as a solvent, solvent dosage of 10V, plus 2.5eq sodium hydride

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is a 5-membered heteroaromatic ring containing 1-4 heteroatoms selected from O, S, N or NH, wherein said ring is optionally fused to a 6-membered monocyclic or 10-membered bicyclic carbocyclic or heterocyclic, aromatic or non-aromatic ring, wherein Ht is optionally substituted with w occurrences of -WRw, wherein w is 0-5; ring A is 3-7 membered monocyclic ring having 0-3 heteroatoms selected from O, S, N, or NH, wherein ring A is optionally substituted with q occurrences of QRQ; ring B is optionally fused to 5-6 membered carbocyclic or heterocyclic, aromatic or non-aromatic ring .