186350-56-1

Usage

Uses

Used in Peptide Synthesis:
N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine serves as a crucial component in the synthesis of peptides, where its protective groups allow for the controlled assembly of peptide chains. This selective protection and deprotection mechanism ensures the accurate formation of peptide bonds and the correct sequence of amino acids, which is essential for the biological activity and stability of the final peptide product.
Used in Pharmaceutical Development:
In the pharmaceutical industry, N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine is utilized as a building block for the creation of therapeutic peptides. These peptides can target specific biological pathways or receptors, offering potential treatments for a range of diseases and conditions. N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine's role in peptide synthesis is vital for the development of new drugs with high specificity and efficacy.
Used in Drug Delivery Systems:
N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine also plays a role in the design of drug delivery systems, where its incorporation into peptides can enhance the stability, solubility, and targeted delivery of therapeutic agents. This can lead to improved pharmacokinetics and pharmacodynamics, reducing side effects and increasing the therapeutic index of drugs.
Used in Biochemical Research:
In the field of biochemical research, N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine is employed as a tool for studying peptide structure and function. Its ability to protect and deprotect specific residues in peptides allows researchers to probe the interactions between peptides and their targets, as well as to investigate the mechanisms of peptide folding and stability.
Overall, N-alpha-Allyloxycarbonyl-N-epsilon-(9-fluorenylmethyloxycarbonyl)-L-lysine is a versatile and essential compound in the realms of organic chemistry, pharmaceutical development, drug delivery, and biochemical research, contributing significantly to the advancement of peptide-based therapies and understanding of peptide biology.

Upstream product

• 84624-28-2 N-(fluorenyl-9-methoxycarbonyl)-L-lysine 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 696660-84-1 [(2S,5R,8S,11S)-8-[4-((S)-2-Amino-3-hydroxy-propionylamino)-butyl]-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid 
• 161552-03-0 [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid 
• 343312-27-6 cyclo(-Gly-Asp-D-Phe-Lys(CO-CH₂ONH₂)-Arg-) 

Relevant academic research and scientific papers

A convenient access to αVβ3/αVβ5 integrin ligand conjugates: Regioselective solid-phase functionalisation of an RGD based peptide

The cyclopeptide (-RGDfK-) is a potent and selective αVβ3/αVβ5 integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and flexible chemical entry to conjugated integrin ligands bearing reporter groups for biological investigations or reactive chemical functions for the preparation of new vector systems.