696660-84-1

Upstream product

• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 86123-10-6 Fmoc-D-Phe-OH 
• 186350-56-1 Alloc-L-Lys(N-Fmoc)-OH 
• 226559-04-2 c(-Arg(Pbf)-Gly-Asp(OtBu)-DPhe-Lys-) 
• 161552-03-0 [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid 
• 146982-24-3 N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester 
• 343312-39-0 cyclo(-D(tBu)-f-K(Aloc)-R(Pmc)-G-) 
• 388633-54-3 C₄₅H₆₇N₉O₁₀S 
• 146982-27-6 (S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 

Downstream Products

• 343312-28-7 cyclo(-Gly-Asp-D-Phe-Lys(CO-COH)-Arg-) 

Relevant academic research and scientific papers

OPTIMISED MULTIVALENT TARGETING FLUORESCENT TRACER

A fluorescent tracer comprises: a RAFT template, comprising the residues: Glycine-Proline-Lysine-Alanine-Lysine-Glycine-Proline-Lysine-Lysine-Lysine and having a mean plane defining an upper face having four lysine residues and a lower face having one lysine residue, four identical targeting molecules comprising the amino acids: Arginine-Glycine-Aspartic acid-Phenylalanine-Lysine (RGDKf), each of the molecules being fixed to a different lysine residue of the first upper face via an oxime bond, and a fluorophore S0456 fixed to the lower face of the mean plane via a spacer arm connecting the central carbon of the sequence of double bonds of the fluorophore and the lysine amino acid of the lower face of the decapeptide via an amide bond, the spacer arm being 5-(4-hydroxyphenyl)pentanoic acid.

Site-selective three-component reaction for dual-functionalization of peptides

A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein. The Royal Society of Chemistry 2013.

A convenient access to αVβ3/αVβ5 integrin ligand conjugates: Regioselective solid-phase functionalisation of an RGD based peptide

The cyclopeptide (-RGDfK-) is a potent and selective αVβ3/αVβ5 integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and flexible chemical entry to conjugated integrin ligands bearing reporter groups for biological investigations or reactive chemical functions for the preparation of new vector systems.