186368-98-9

Upstream product

• 51219-18-2 Boc-Arg(Cbz)-OH 
• 51219-20-6 ((S)-1-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-2-oxo-piperidin-3-yl)-carbamic acid tert-butyl ester 
• 84052-82-4 [1-Amino-1-((S)-3-amino-2-oxo-piperidin-1-yl)-meth-(E)-ylidene]-carbamic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 186368-97-8 ((R)-5-{[((S)-1-{Amino-[(E)-benzyloxycarbonylimino]-methyl}-2-oxo-piperidin-3-ylcarbamoyl)-methyl]-carbamoyl}-5-tert-butoxycarbonylamino-pentyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Design, synthesis and structure-activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: Structures based on the (D)- Arg-Gly-Arg tripeptide sequence

A series of arginine aldehyde inhibitors was designed as transition state (TS) analogues based on the known factor Xa specific substrate Cbz-D- Arg-Gly-Arg-pNA. BnSO2-(D)Arg-Gly-Arg-H (20) was found to be the most potent and selective inhibitor of factor Xa and prothrombinase activity in this series.