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186386-21-0

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186386-21-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 186386-21-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,3,8 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 186386-21:
(8*1)+(7*8)+(6*6)+(5*3)+(4*8)+(3*6)+(2*2)+(1*1)=170
170 % 10 = 0
So 186386-21-0 is a valid CAS Registry Number.

186386-21-0Downstream Products

186386-21-0Relevant articles and documents

Synthesis, pharmacology and pharmacokinetics of 3-(4-Arylpiperazin-1-ylalkyl)-uracils as uroselective α1A-antagonists

Lopez,Arias,Chan,Clarke,Elworthy,Ford,Guzman,Jaime-Figueroa,Jasper,Morgans Jr.,Padilla,Perez-Medrano,Quintero,Romero,Sandoval,Smith,Williams,Blue

, p. 1873 - 1878 (2007/10/03)

Predominance in the urethra and prostate of the α1A-adrenoceptor subtype, which is believed to be the receptor mediating noradrenaline induced smooth muscle contraction in these tissues, led to the preparation of α1A-selective antagonists to be tested as uroselective compounds for the treatment of benign prostatic hyperplasia. Thus, a number of selective α1A-adrenoceptor antagonists were synthesized and assayed in vitro for potency and selectivity. Dog pharmacokinetic parameters of 12 (RO700004) and its metabolite 40 (RO1104253) were established. The relative selectivity of intravenously administered 12, 40 and standard prazosin to inhibit hypogastric nerve stimulation-induced increases in intraurethral prostatic pressure versus phenylephrine-induced increases in diastolic blood pressure in anesthetized dogs was 76, 71 and 0.6, respectively.

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