186406-69-9

Upstream product

• 114934-98-4 2,5-di-O-benzyl-1,6-bis-O-tert-butyldiphenylsilanyl-D-mannitol 
• 135840-23-2 (2R,3S)-2-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-5-en-3-ol 
• 135840-26-5 (2R,4S,5R)-5-benzyloxy-6-(tert-butyldiphenylsilyl)oxy-4-methoxy-2-methyl-1-hexanol 
• 135840-25-4 (2R,3S)-2-O-benzyl-1-O-tert-butyldiphenylsilyl-3-O,5-dimethyl-5-hexene-1,2,3-triol 
• 186406-67-7 (E)-(2R,4S,5S,8S,12R)-7-Benzenesulfonyl-1,5-bis-benzyloxy-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2,8,10-trimethyl-pentadeca-10,14-dien-6-one 
• 186406-66-6 (E)-(2R,4S,5R,8S,12R)-7-Benzenesulfonyl-1,5-bis-benzyloxy-12-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-2,8,10-trimethyl-pentadeca-10,14-dien-6-ol 
• 135840-28-7 (2R,4S,5S,8S,10E,12R)-1,5-dibenzyloxy-12-(tert-butyldimethylsilyl)oxymethyl-4-methoxy-2,8,10-trimethyl-10,14-pentadecadien-6-one 
• 186406-58-6 (2R,3S,5R)-2,6-dibenzyloxy-1-(tert-butyldiphenylsilyl)oxy-3-methoxy-5-methylhexane 
• 122598-86-1 2-O-Benzyl-3-O-(tert-butyldiphenylsilyl)glyceraldehyde 
• 135840-21-0 (4R,5E,8S)-4-(tert-butyldimethylsilyl)oxymethyl-6,8-dimethyl-9-(phenylsulfonyl)-1,5-nonadiene 
• 135840-27-6 (2S,3S,5R)-2,6-dibenzyloxy-3-methoxy-5-methylhexanal 
• 186406-59-7 (2R,3S,5R)-2,6-dibenzyloxy-3-methoxy-5-methyl-1-hexanol 
• 186406-57-5 (2S,4E,6R)-6-(tert-butyldimethylsilyl)oxymethyl-2,4-dimethyl-4,8-nonadienyl methanesulfonate 
• 135840-19-6 (2S,4E,6R)-6-(tert-butyldimethylsilyl)oxymethyl-2,4-dimethyl-4,8-nonadienoic acid 

Relevant academic research and scientific papers

Stereocontrolled synthesis of C10-C22 fragment of the immunosuppressant FK 506. An occurrence of complementary stereoselectivity in the C15 ketone reduction

The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3, which could be constructed by highly stereocontrolled ester-enolate Claise