186428-92-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 122654-37-9 3-(S)-O-{[(1,1-dimethyl)ethyl dimethylsilyl]oxy}-γ-butyrolactone 
• 100-46-9 benzylamine 

Downstream Products

• 186428-91-1 (S)-N-benzyl-4-tert-butyldimethylsilyloxy-pyrrolidin-2-one 
• 186428-93-3 methanesulfonic acid 3-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester 

Relevant academic research and scientific papers

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone ((5)-2) and (R)4- acetylthio-2-pyrrolidinone (S), which are key intermediates of oral carbapenem CS-834, were studied. The most efficient route to (S)-2 from (S)- 3-hydroxybutyrolactone (8) was accomplished in high yield via (S)-N-allyl-3- (1-ethoxy)ethoxy-4-hydroxybutyramide (14).