186428-91-1

Upstream product

• 122654-37-9 3-(S)-O-{[(1,1-dimethyl)ethyl dimethylsilyl]oxy}-γ-butyrolactone 
• 186428-92-2 (S)-N-benzyl-3-t-butyldimethylsilyloxy-4-hydroxybutyramide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-39-0 benzyl bromide 
• 141629-19-8 (4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one 
• 186428-93-3 methanesulfonic acid 3-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-propyl ester 

Downstream Products

• 1432128-77-2 C₁₉H₃₁NOSi 
• 1432128-80-7 C₁₃H₁₇NO 
• 913566-62-8 (S)-1-benzyl-4-(a-diazoacetoxy)pyrrolidin-2-one 
• 191403-66-4 (S)-N-benzyl-4-hydroxy-pyrrolidin-2-one 

Relevant academic research and scientific papers

Preparation of (S)-N-Substituted 4-Hydroxy-pyrrolidin-2-ones by Regio- and Stereoselective Hydroxylation with Sphingomonas sp. HXN-200

formula presented Enantiopure (S)-N-substituted 4-hydroxy-pyrrolidin-2-ones have been prepared for the first time by regio- and stereoselective hydroxylation of the corresponding pyrrolidin-2-ones by use of a biocatalyst. Hydroxylation of 6 and 8 with Sph

Synthesis of nature product kinsenoside analogues with anti-inflammatory activity

Kinsenoside is the major bioactive component from herbal medicine with a broad range of pharmacological functions. Goodyeroside A, an epimer of kinsenoside, remains less explored. In this report we chemically synthesized kinsenoside, goodyeroside A and their analogues with glycan variation, chirality inversion at chiral center(s), and bioisosteric replacement of lactone with lactam. Among these compounds, goodyeroside A and its mannosyl counterpart demonstrated superior anti-inflammatory efficacy. Furthermore, goodyeroside A was found to suppresses inflammatory through inhibiting NF-κB signal pathway, effectively. Structure-activity relationship is also explored for further development of more promising kinsenoside analogues as drug candidates.

Gamma-lactam glycoside derivative, and synthesis method and application thereof

The invention relates to a gamma-lactam glycoside derivative, and a synthesis method and application thereof. The structure of the formula I is shown as follows (please see the specification for the formula I), wherein R is selected from a beta-D-glucopyranose group, an alpha-D-glucopyranose group, a beta-D-galactopyranose group, an alpha-D-galactopyranose group, a beta-D-mannopyranose group, an alpha-D-mannopyranose grop, a beta-D-xylopyranose group, an alpha-D-xylopyranose group, a beta-L-pyran rhamnose group and an alpha-L-pyran rhamnose group, and the bond shown in the specification represents pointing to the page or the bond shown in the specification represents pointing out of the page.

Nonracemic bicyclic lactam lactones via regio- and cis-diastereocontrolled C-H insertion. Asymmetric synthesis of (8S,8aS)-octahydroindolizidin-8-ol and (1S,8aS)-octahydroindolizidin-1-ol

(Chemical Equation Presented) The Rh2(MPPIM)4- catalyzed intramolecular C-H insertion reaction of (S)- and (R)-1-benzyl-5-(R- diazoacetoxy)piperidin-2-one and (S)-1-benzyl-4-(α-diazoacetoxy) pyrrolidin-2-one proceeds with high regios

Regio- and diastereocontrolled C-H insertion of chiral γ- and δ-lactam diazoacetates. Application to the asymmetric synthesis of (8S,8aS)-8-hydroxyindolizidine

γ- and δ-Lactam diazoacetates undergo efficient intramolecular C-H insertion catalyzed by Rh2(MPPIM)4 with excellent regioselectivity and cis-diastereoselectivity to provide synthetically useful bicyclic lactam lactones. The Royal So

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone ((5)-2) and (R)4- acetylthio-2-pyrrolidinone (S), which are key intermediates of oral carbapenem CS-834, were studied. The most efficient route to (S)-2 from (S)- 3-hydroxybutyrolactone (8) was accomplished in high yield via (S)-N-allyl-3- (1-ethoxy)ethoxy-4-hydroxybutyramide (14).