186461-76-7

Upstream product

• 118289-17-1 2-bromopyridine-4-carboxaldehyde 
• 70461-33-5 2-bromo-4,5-dimethoxybenzaldehyde dimethyl acetal 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-1,2,3,4 -TETRAHYDROQUINOLINES

The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]: [wherein R 1 represents a hydrogen atom or a protecting group for amino group.] with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; and if necessary, subjecting the reaction product to solvolysis.

OPTICALLY ACTIVE CYCLIC ALCOHOL COMPOUND AND METHOD FOR PRODUCING SAME

Disclosed is a method for producing an optically active cyclic alcohol compound represented by the general formula [I] below, wherein a cyclic ketone compound represented by the general formula [II] below is asymmetrically reduced in the presence of (A) an optically active oxazaborolidine compound and a boron hydride compound, or alternatively in the presence of (B) an asymmetric transition metal complex obtained from a transition metal compound and an asymmetric ligand, and a hydrogen donor. Also disclosed is such an optically active cyclic alcohol compound. [I] (In the formula, the symbol is as defined below.) [II] (In the formula, R represents a hydrogen atom or a protective group of an amino group.)

1-arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor

1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan s

Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: Synthesis and biological activities of a series of 1- pyridylnaphthalene derivatives

The structural requirements for potent and selective PDE4 inhibition were revealed in a 1-pyridylnaphthalene series, and the best compound (3kg, T-2585·HCl) was chosen for further biological evaluation (PDE4 inhibition IC50 = 0.13 nM, selectivi

A synthesis of 1-pyridylnaphthalene lignan analogs

A new series of 1-arylnaphthalene lignan analogs having a variety of pyridyl substituents at the C-1 position were synthesized in moderate to good yields by means of the Diels-Alder reaction by utilizing 1-pyridylisobenzofuran precursors with dimethyl fumarate, methyl acrylate, or dimethyl acetylene dicarboxylate, followed by BF3·Et2O-mediated aromatization.