18648-11-8

Basic information

• Product Name: Benzoic acid, 3-(aminosulfonyl)-, hydrazide
• CAS NO: 18648-11-8
• Molecular Formula: C7H9N3O3S
• Molecular Weight: 215.233
• Mol File: 18648-11-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-(aminosulfonyl)-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-(aminosulfonyl)-, hydrazide(18648-11-8)
• EPA Substance Registry System: Benzoic acid, 3-(aminosulfonyl)-, hydrazide(18648-11-8)

Safety Data

• Hazardous Substances Data: 18648-11-8(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 59777-67-2 methyl 3-(aminosulfonyl)benzoate 
• 636-76-0 3-sulfamoylbenzoic acid 

Downstream Products

• 1423715-34-7 (E)-3-(2-(1-(5-chloro-2-hydroxyphenyl)ethylidene)hydrazinecarbonyl)benzenesulfonamide 

Relevant articles and documents

3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation

A new series of benzenesulphonamide linked-1,3,4-oxadiazole hybrids (6a–s) has been synthesized and tested for their carbonic anhydrase inhibition against human (h) carbonic anhydrase (CA) isoforms hCA I, II, IX, and XIII. Fluorescence properties of some of the synthesized molecules were studied. Most of the molecules exhibited significant inhibitory power, comparable or better than the standard drug acetazolamide (AAZ) on hCA XIII. Out of 19 tested molecules, compound 6e (75.8 nM) was 3 times more potent than AAZ (250.0 nM) against hCA I, whereas compound 6e (15.4 nM), 6g (16.2 nM), 6h (16.4 nM) and 6i (17.0 nM) were found to be more potent than AAZ (17.0 nM) against isoform hCA XIII. It is anticipated that these compounds could be taken as the potential leads for the development of selective hCA XIII isoform inhibitors with improved potency.

Diuretics. 4-substituted 3-sulfamoylbenzoic acid hydrazides.

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