186489-77-0

Upstream product

• 186489-76-9 1-{(Z)-(1S,2R)-1-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-methyl-3-trimethylsilanyloxy-pent-3-enyloxymethyl}-4-methoxy-benzene 
• 186489-70-3 (4R)-4-benzyl-3-{(2R)-2-[(4S,5R,6S)-6-((1S)-2-hydroxy-1-methylethyl)-2,2,5-trimethyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone 
• 171230-15-2 (4R)-4-benzyl-3-{(2R)-2-[(4S,5R,6S)-6-((1R)-2-oxo-1-methylethyl)-2,2,5-trimethyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone 
• 186489-75-8 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-[(p-methoxybenzyl)oxy]-4,6-dimethylnonan-3-one 
• 186489-74-7 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-hydroxy-4,6-dimethylnonan-3-one 
• 171005-61-1 (R)-4-Benzyl-3-((R)-2-{(4S,5R,6S)-6-[(1S,2S,3R,5R,6S,7R,8R)-8-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-1,3,5,7-tetramethyl-4-oxo-decyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionyl)-oxazolidin-2-one 

Downstream Products

• 186489-78-1 C₄₈H₇₅NO₁₀Si 

Relevant academic research and scientific papers

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.