186489-76-9

Upstream product

• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 186489-75-8 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-[(p-methoxybenzyl)oxy]-4,6-dimethylnonan-3-one 
• 186489-71-4 (4R,2'R,4'S)-3-(2',4'-dimethyl-3'-oxo-5'-hydroxyheptanoyl)-4-benzyl-2-oxazolidinone 
• 186489-72-5 (4R,2'R,3'S,4'S)-3-(2',4'-dimethyl-3',5'-dihydroxyheptanoyl)-4-benzyl-2-oxazolidinone 
• 211187-30-3 (2R,3S,4R,5R)-5-(t-butyldimethylsilyloxy)-3-hydroxy-N-methoxy-N,2,4-trimethylheptanamide 
• 186489-74-7 (4R,5S,6R,7R)-7-(t-butyldimethylsilyloxy)-5-hydroxy-4,6-dimethylnonan-3-one 
• 186489-73-6 (R)-4-Benzyl-3-[(2R,3S,4R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-heptanoyl]-oxazolidin-2-one 
• 101712-01-0 (R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 186489-77-0 (R)-4-Benzyl-3-((R)-2-{(4S,5R,6S)-6-[(1S,2R,3S,4S,5S,6R,7R,8R)-8-(tert-butyl-dimethyl-silanyloxy)-2,4-dihydroxy-6-(4-methoxy-benzyloxy)-1,3,5,7-tetramethyl-decyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionyl)-oxazolidin-2-one 

Relevant academic research and scientific papers

General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.