186493-53-8

Upstream product

• 128622-94-6 N-(3-chloro-propyl)-N-methyl-aniline 
• 10035-10-6 hydrogen bromide 
• 34579-44-7 N-Methyl,N-{(3-hydroxy)-1-propyl}aniline 
• 109-64-8 1,3-dibromo-propane 
• 100-61-8 N-methylaniline 

Downstream Products

• 47233-87-4 N,N'-dimethyl-N,N'-diphenyl-1,6-hexanediamine 
• 1452855-71-8 4-((3-(methyl(phenyl)amino)propyl)thio)phenol 
• 1431659-32-3 4-(3-(methyl(phenyl)amino)propoxy)phenol 
• 1235866-14-4 9-O-[3-(N-methyl-phenylamino)propyl]berberine bromide 
• 252967-02-5 N-Methyl-N-{(p-formylphenoxy)-1-propyl}aniline 
• 252967-01-4 N-Methyl-N-{(o-formylphenoxy)-1-propyl}aniline 

Relevant academic research and scientific papers

Transition metal- And light-free radical borylation of alkyl bromides and iodides using silane

We report operationally simple and neutral conditions for borylation of alkyl bromides and iodides to alkyl boronic esters under transition metal- and light-free conditions. A series of substrates with a wide range of functional groups were effectively transformed into the borylation products in moderate to good yields. Mechanistic studies, including radical clock experiments and DFT calculations, gave detailed insight into the radical borylation process.

Novel glycoconjugated squaraine dyes for selective optical imaging of cancer cells

Novel glycoconjugated squaraine dyes were synthesized, which exhibited excellent internalization in tumor cells and are potent fluorogenic imaging probes for tumor selective optical imaging.

Targeted dendrimer-drug conjugates

The invention provides for dendrimer conjugates useful for liver-specific delivery of therapeutic agents. The therapeutic agent is associated to the dendrimer through a enzyme-cleavable covalent linkage.

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia

This study explores the possible use of reactive oxygen-activated DNA modifying agents against acute myeloid leukemia (AML). A key amine on the lead agent was investigated via cytotoxicity assays and was found necessary for potency. The two best compounds were screened via the NCI-60 cell panel. These two compounds had potency between 200 and 800 nM against many of the leukemia cancer cell types. Subsequent experiments explored activity against a transformed AML model that mimics the molecular signatures identified in primary AML patient samples. A lead compound had an IC50 of 760 nM against this AML cell line as well as a therapeutic index of 7.7 ± 3 between the transformed AML model cell line and non-cancerous human CD34+ blood stem/progenitor cells (UCB). The selectivity was much greater than the mainstays of AML treatment: doxorubicin and cytarabine. This manuscript demonstrates that this novel type of agent may be useful against AML.

ROS-Activated Compounds as Selective Anti-Cancer Therapeutics

Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase

A series of novel berberine derivatives were designed, synthesized, and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among these derivatives, compound 48a, berberine linked with 3-methylpyridi

Orientation-dependent electron transfer processes in fullerene-aniline dyads

Synthesized o- and p-substituted fullerene-aniline dyads exhibited orientation-dependent electron transfer under photoexcitation. The experimental evidence based on steady state and time-resolved spectroscopy was in agreement with the computational studie

Synthesis, characterization, photophysics, and photosensitization studies of squaraine-bipyridinium diads

Two squaraine-bipyridinium diads designed to study electron transfer between the squaraine chromophore and the bipyridinium group have been synthesized. The two diads, denoted as C4Sq-By and C12Sq-By, consist of amphiphilic squaraines covalently linked to a bipyridinium group by a trimethylene chain. The squaraine chromophores in the diads do not form charge-transfer complexes with the bipyridinium group in the ground state. Both C4Sq-By and C12Sq-By show fluorescence yields about 100 times weaker than those of alkyl substituted squaraines, which is attributed to quenching by an intramolecular electron transfer from the excited squaraine chromophore to the bipyridinium; the intramolecular electron-transfer rate is estimated to be 4 × 1011 s-1. Assuming the short lifetime for the undetectable transient produced is due to very fast back electron transfer to the radical cation of squaraine from the reduced bipyridinium ion, the rate of the back intramolecular electron transfer is estimated as >3 ×1010 s-1. The two diads synthesized in this work have been used as photocurrent enhancers for the monolayers of DSSQ (4-(distearylamino)phenyl-4′-(dimethylamino)phenylsquaraine). C4Sq-By as a solution additive is 5 times more effective in sensitizing the cathodic photocurrent generation of the DSSQ monolayer-modified SnO2 electrode compared to methylviologen. Analogously, C12Sq-By is 3 times more effective in sensitizing the DSSQ monolayer-modified SnO2 electrode compared to 4-tetradecyl-4′-methylbipyridinium dichloride when it is incorporated upon spreading in the monolayer of DSSQ. The increase in cathodic photocurrent generation efficiency is postulated to result from fast electron transfer from the excited squaraine to the bipyridinium group in the diad. The fast electron transfer facilitates electron separation in the photogeneration step and consequently increases the quantum efficiency of the cathodic photocurrent generation process.