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1865-56-1

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  • (10R,13S)-17-chloro-16-forMyl- 10,13-diMethyl-2,3,4,7,8,9,10, 11,12,13,14,15-dodecahydro- 1H-cyclopenta[a]phenanthren-3- yl acetate

    Cas No: 1865-56-1

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  • Senova Pharma
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  • (10R,13S)-17-Chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

    Cas No: 1865-56-1

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  • (10R,13S)-17-Chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate cas 1865-56-1

    Cas No: 1865-56-1

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1865-56-1 Usage

General Description

The chemical "(10R,13S)-17-chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate" is a complex organic compound with a steroid structure. It contains a chloro group and a formyl group at specific positions on the steroid backbone, as well as an acetate functional group. The compound also features two methyl groups at positions 10 and 13. This chemical is likely to have biological activity due to its steroid structure, and it may be used in pharmaceutical research or other applications related to steroids and hormonal regulation.

Check Digit Verification of cas no

The CAS Registry Mumber 1865-56-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,6 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1865-56:
(6*1)+(5*8)+(4*6)+(3*5)+(2*5)+(1*6)=101
101 % 10 = 1
So 1865-56-1 is a valid CAS Registry Number.

1865-56-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [(3S,10R,13S)-17-chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

1.2 Other means of identification

Product number -
Other names CX1340

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1865-56-1 SDS

1865-56-1Relevant articles and documents

Heterocyclic steroids: Synthesis of androsteno[17,16-d]pyrazoles and androsteno[17,16-e]pyrimidines

Siddiqui,Rao,Maimirani,Siddiqui

, p. 353 - 354 (1995)

The Vilsmeier-Haack reaction of 3β-acetoxyandost-5-en-17-one (1) with phosphorous oxychloride and dimethylformamide gave 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene (2). Reaction of 2 with hydrazine and phenylhydrazine provided substituted 5-androst

Discovery and development of galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer

Njar, Vincent C. O.,Brodie, Angela M. H.

, p. 2077 - 2087 (2015)

In our effort to discover potent and specific inhibitors of 17α-hydroxylase/17,20-lyase (CYP17), the key enzyme which catalyzes the biosynthesis of androgens from progestins, 3β-(hydroxy)-17-(1H-benzimidazole-1-yl)androsta-5,16-diene (Galeterone or TOK-001, formerly called VN/124-1) was identified as a selective development candidate which modulates multiple targets in the androgen receptor (AR) signaling pathway. This drug annotation summarizes the mechanisms of action, scientific rationale, medicinal chemistry, pharmacokinetic properties, and human efficacy data for galeterone, which has successfully completed phase II clinical development in men with castration resistant (advanced) prostate cancer (CRPC). Phase III clinical studies in CRPC patients are scheduled to begin in early 2015.

Novel steride androgen receptor antagonist, preparation method and medical application thereof

-

Paragraph 0016; 0018; 0019; 0021; 0022; 0024; 0054-0056, (2018/04/21)

The invention relates to the field of medicinal chemistry, in particular to a series of steride androgen receptor antagonist, and a preparation method and medical application thereof, and particularlyrelates to a medicine for treating androgen receptor related diseases, such as cell proliferation depending on androgens, hirsutism, acnes and androgen alopecia. The general molecular formula of thecompound is shown as follows, and groups in the formula are specified in the specification.

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

Komendantova, Anna S.,Komkov, Alexander V.,Volkova, Yulia A.,Zavarzin, Igor V.

supporting information, p. 4247 - 4254 (2018/08/24)

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

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