18652-74-9

Basic information

• Product Name: erythro-2-bromo-3-hydroxy-3-phenylpropan-1-ol
• CAS NO: 18652-74-9
• Molecular Weight: 231.089
• Mol File: 18652-74-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: erythro-2-bromo-3-hydroxy-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-2-bromo-3-hydroxy-3-phenylpropan-1-ol(18652-74-9)
• EPA Substance Registry System: erythro-2-bromo-3-hydroxy-3-phenylpropan-1-ol(18652-74-9)

Safety Data

• Hazardous Substances Data: 18652-74-9(Hazardous Substances Data)

Upstream product

• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 104-54-1 3-Phenylpropenol 
• 36808-12-5 rac-(2R,3S)-2,3-dibromo-3-phenylpropan-1-ol 

Downstream Products

• 5817-02-7 (2RS,3RS)-3-amino-3-phenyl-propane-1,2-diol 

Relevant articles and documents

Catalytic enantioselective bromohydroxylation of cinnamyl alcohols

This work describes an effective enantioselective bromohydroxylation of cinnamyl alcohols with (DHQD)2PHAL as the catalyst and H2O as the nucleophile, providing a variety of corresponding optically active bromohydrins with up to 95% ee.

Method for synthesizing photoactive bromohydrin compound

The invention discloses a method for synthesizing a photoactive bromohydrin compound, which comprises the following steps: reacting cinnamyl alcohol as shown in a formula I, benzamide bromide as shown in a formula II, a quinine derivative, L-camphorsulfonic acid and water in a first organic solvent to obtain the bromohydrin compound as shown in a formula III. According to the method, raw materials are easy to synthesize, reaction conditions are mild, operation is easy and convenient, the yield reaches up to 47%-87%, enantioselectivity can generally reach 80% or above, and the highest point can even reach 95%.

From simple organobromides or olefins to highly value-added bromohydrins: A versatile performance of dimethyl sulfoxide

A novel and efficient direct transformation of secondary bromides or olefins to highly value-added bromohydrins has been disclosed. Dimethyl sulfoxide (DMSO), a cheap and common solvent, performs its versatile role as a solvent, an essential oxidant, and also as an oxygen source in this bromohydrin synthesis.