186525-22-4Relevant academic research and scientific papers
Novel C-2 substituted carbapenem derivatives. Part I. Synthesis and biological activity of non-aromatic heterocyclic derivatives
Burton, George,Clear, Nicola J. C.,Eglington, A. John,Guest, Angela W.,Hunt, Eric,Naylor, Antoinette,Pearson, Michael J.,Takle, Andrew K.
, p. 1258 - 1265 (2007/10/03)
A new series of carbapenems, having a saturated or partially unsaturated heterocycle at C-2, has been synthesised. The in vitro antibacterial activity of these compounds and their stability to human dehydropeptidase-1 (DHP-1) are described. The stereochemistry of the C-2 side-chain and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.
