64370-70-3

Upstream product

• 114409-25-5 di-p-methoxybenzyl fumarate 
• 75-18-3 dimethylsulfide 

Downstream Products

• 132114-42-2 [2-(1-Acetoxy-allyl)-5-oxo-pyrrolidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 
• 138477-43-7 ((2R,3R)-2-Allyl-3-bromo-4-oxo-azetidin-1-yl)-hydroxy-acetic acid 4-methoxy-benzyl ester 
• 112076-96-7 {(2R,3S)-2-((R)-3-Acetoxy-1-methyl-2-oxo-propyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 
• 126747-45-3 [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-((R)-(S)-1-oxiranyl-ethyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 
• 125013-06-1 (5R,6R)-p-methoxybenzyl 6-bromo-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 125013-04-9 (3'R,4'R)-p-methoxybenzyl (4'-allyl-3'-bromo-2'-oxoazetidin-1'-yl)(triphenylphosphoranylidene)acetate 
• 125013-09-4 (5R)-p-methoxybenzyl 6-<(E)-(1-methyl-1H-1,2,3-triazol-4-yl)methylene>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 125013-10-7 (5R)-p-methoxybenzyl 6-<(Z)-(1-methyl-1H-1,2,3-triazol-4-yl)methylene>-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 125013-08-3 (R)-6-[Acetoxy-(1-methyl-1H-[1,2,3]triazol-4-yl)-methyl]-6-bromo-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 125013-05-0 [(3R,4R)-3-Bromo-2-oxo-4-(2-oxo-ethyl)-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 
• 132114-45-5 (1S,7aR)-1-Acetoxy-5-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylic acid 4-methoxy-benzyl ester 
• 135238-08-3 p-Methoxybenzyl (1R*,5R*,6S*)-1-methyl-6-<(4S*)-4-methyl-2-oxo-1,3-dioxolan-4-yl>carbapen-2-em-3-carboxylate 
• 135238-08-3 p-Methoxybenzyl (1S*,5R*,6S*)-1-methyl-6-<(4S*)-4-methyl-2-oxo-1,3-dioxolan-4-yl>carbapen-2-em-3-carboxylate 

Relevant academic research and scientific papers

Process for the preparation of penem compounds and intermediates for this preparation

Compounds of the general formula I in which, X denotes a halogen atom;, Y denotes a hydrogen atom, a halogen atom, or a moiety of the general formula II Z denotes a halogen atom, a hydroxy group, a substituted hydroxy group, an -S(O)nR5 group, or an -Se(O)mR5 group;, n denotes 0, 1 or 2, preferably 0 or 1;, m denotes 0 or 1;, R3 denotes a hydrogen atom or an organic group;, R4 denotes a hydrogen atom, a carboxy-salt-forming ion, or a carboxy-ester-forming group;, R5 denotes a hydrogen atom, a hydrocarbon group, or a heterocyclyl group; and, R12 denotes a hydrogen atom, an unsubstituted or substituted hydrocarbon group, or an unsubstituted or substituted heterocyclyl group;, are novel intermediates useful in the preparation of 6-methylene-penems of the general formula X: