186552-07-8

Basic information

• Product Name: 4-Bromomethyl-thiophene-2-carbonitrile
• Synonyms: 4-Bromomethyl-thiophene-2-carbonitrile
• CAS NO: 186552-07-8
• Molecular Formula: C₆H₄BrNS
• Molecular Weight: 202.07166
• Mol File: 186552-07-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Bromomethyl-thiophene-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromomethyl-thiophene-2-carbonitrile(186552-07-8)
• EPA Substance Registry System: 4-Bromomethyl-thiophene-2-carbonitrile(186552-07-8)

Safety Data

• Hazardous Substances Data: 186552-07-8(Hazardous Substances Data)

Upstream product

• 558-13-4 carbon tetrabromide 
• 603-35-0 triphenylphosphine 
• 186552-06-7 4-(hydroxymethyl)thiophene-2-carbonitrile 
• 73305-93-8 4-methylthiophene-2-carbonitrile 
• 498-62-4 3-thiophene carboxaldehyde 
• 185395-90-8 (5-iodo-thiophene-3-yl)methanol 
• 18799-85-4 5-iodo-thiophene-3-carboxaldehyde 

Downstream Products

• 1027481-51-1 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (5-cyano-thiophen-3-ylmethyl)-amide 
• 1027227-14-0 ((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid methyl ester 
• 1025879-96-2 C₂₆H₂₇N₅O₄S₂ 
• 1026963-96-1 ((R)-1-{(S)-2-[(5-Cyano-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethylamino)-acetic acid tert-butyl ester 
• 186549-27-9 RPR120844 
• 280781-47-7 (S)-1-((R)-2-Methanesulfonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (5-cyano-thiophen-3-ylmethyl)-amide 
• 232280-77-2 4-aminomethyl-thiophene-2-carbonitrile 

Relevant articles and documents

N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS

A compound of formula (I), or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between S100A9 and interaction partners such as RAGE, TLR4 and EMMPRIN and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.

Thrombin inhibitors

Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

Thrombin inhibitors

The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are useful as anticoagula