186593-14-6

Basic information

• Product Name: 5-(TRIFLUOROMETHYL)PYRIDIN-3-OL
• Synonyms: 5-(TRIFLUOROMETHYL)PYRIDIN-3-OL
• CAS NO: 186593-14-6
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.1
• Mol File: 186593-14-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 301.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.28±0.10(Predicted)
• CAS DataBase Reference: 5-(TRIFLUOROMETHYL)PYRIDIN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(TRIFLUOROMETHYL)PYRIDIN-3-OL(186593-14-6)
• EPA Substance Registry System: 5-(TRIFLUOROMETHYL)PYRIDIN-3-OL(186593-14-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 186593-14-6(Hazardous Substances Data)

Usage

Uses

5-(Trifluoromethyl)pyridin-3-ol is used in preparation of tricyclic dihydroimidazopyrimidone derivative as as lipoprotein-associated phospholipase A2 inhibitor.

Upstream product

• 85148-26-1 3-chloro-5-(trifluoromethyl)pyridine 

Downstream Products

• 1270497-74-9 cis-5-(trifluoromethyl)piperidin-3-ol 
• 1369255-51-5 5-formyl-2-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile 
• 1369255-53-7 5-(hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzonitrile 
• 1620579-56-7 3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde 
• 1421434-98-1 (3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)phenyl)methanol 

Relevant articles and documents

DUAL MAGL AND FAAH INHIBITORS

Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2

The present invention relates to novel pyrimido[1,6-a]pyrimidin-6(2H)-one compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.