1866-01-9

Upstream product

• 50-00-0 formaldehyd 
• 99-87-6 4-methylisopropylbenzene 
• 7647-01-0 hydrogenchloride 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 1866-02-0 5-isopropyl-2-methyl-benzyl alcohol 

Downstream Products

• 859337-99-8 (5-isopropyl-2-methyl-benzyl)-pentachlorophenyl ether 
• 3846-04-6 (5-isopropyl-2-methyl-benzyl)-p-tolyl sulfide 
• 4395-82-8 (5-isopropyl-2-methyl-phenyl)-acetic acid 
• 4132-77-8 3,4-dimethylcumene 
• 854210-26-7 5,5'-diisopropyl-2,2'-dimethyl-bibenzyl 
• 97282-01-4 4-(5-isopropyl-2-methyl-phenyl)-butan-2-one 
• 4389-71-3 3-(5-isopropyl-2-methyl-phenyl)-propionic acid 
• 4389-65-5 5-isopropyl-2-methyl-phenethylamine 
• 884321-96-4 5-(2,6-diethyl-phenyl)-1-(2,5-dimethyl-benzyl)-1H-pyrrolo[2,3-c]pyridine 
• 855657-52-2 (5-isopropyl-2-methyl-benzyl)-malonic acid diethyl ester 
• 4393-12-8 (5-iso-propyl-2-methylphenyl)methanamine 
• 1866-03-1 5-isopropyl-2-methylbenzaldehyde 
• 1866-02-0 5-isopropyl-2-methyl-benzyl alcohol 
• 4478-11-9 (5-isopropyl-2-methyl-phenyl)-acetonitrile 

Relevant academic research and scientific papers

Identification of alkylarene chloromethylation products using gas-chromatographic retention indices

Gas-chromatographic retention indices on standard nonpolar polydimethylsiloxane stationary phases allow identification of products formed by known organic reactions even without using mass-spectrometric data. The efficiency of this approach was demonstrated by the example of identification of previously uncharacterized chloromethyl derivatives of alkylarenes, including structural isomers of compounds containing several chloromethyl groups, directly in reaction mixtures. Chromatographic analysis of such reaction mixtures allows identification of positional isomers of the starting alkylarenes even when they are present simultaneously. The retention indices were determined for the first time for more than 50 alkyl-(chloromethyl)arenes, by-products of chloromethylation, and chloromethyl derivatives of the simplest alkyl phenyl ketones. Nauka/Interperiodica 2007.

PYRROLO-PYRIDINE, PYRROLO-PYRIMIDINE AND RELATED HETEROCYCLIC COMPOUNDS

Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R2, R5, E, Z1, Z3, Z4, and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.