186644-16-6

Basic information

• Product Name: (1-methyl-but-3-ynyl)benzene
• CAS NO: 186644-16-6
• Molecular Weight: 144.216
• Mol File: 186644-16-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1-methyl-but-3-ynyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-but-3-ynyl)benzene(186644-16-6)
• EPA Substance Registry System: (1-methyl-but-3-ynyl)benzene(186644-16-6)

Safety Data

• Hazardous Substances Data: 186644-16-6(Hazardous Substances Data)

Upstream product

• 16251-77-7 3-Phenylbutyraldehyde 
• 851854-16-5 (5,5-dibromopent-4-en-2-yl)benzene 
• 52890-09-2 1,1-Dichlor-4-phenyl-1-penten 

Relevant articles and documents

Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5)

Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.

An improved synthesis of dichloroalkylphosphonates, chloroalkynes and terminal alkynes via diethyl dichloromethylphosphonate

Diethyl 1,1-dichloromethylphosphonate (2) was synthesised in good yield from the reduction of 1,1,1-trichloromethylphosphonate (1) with i-C3H7MgCl and subsequent hydrolysis. The reactivity of 2 towards α-alkylation and its utility in the synthesis of chloroalkynes and terminal alkynes was investigated.